B cells, plasma cells and antibody repertoires in the tumour microenvironment

被引:449
作者
Sharonov, George, V [1 ,2 ,3 ]
Serebrovskaya, Ekaterina O. [2 ,3 ]
Yuzhakova, Diana, V [1 ]
Britanova, Olga, V [1 ,2 ,3 ]
Chudakov, Dmitriy M. [1 ,2 ,3 ,4 ]
机构
[1] Privolzhsky Res Med Univ, Lab Genom Antitumor Adapt Immun, Nizhnii Novgorod, Russia
[2] Shemyakin & Ovchinnikov Inst Bioorgan Chem, Genom Adapt Immun Dept, Moscow, Russia
[3] Pirogov Russian Natl Res Med Univ, Inst Translat Med, Moscow, Russia
[4] Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow, Russia
基金
俄罗斯科学基金会;
关键词
TERTIARY LYMPHOID STRUCTURES; HUMORAL IMMUNE-RESPONSE; BRUTONS TYROSINE KINASE; REGULATORY T-CELLS; BREAST-CANCER; LUNG-CANCER; INFILTRATING LYMPHOCYTES; ANTITUMOR IMMUNITY; ANTIGEN PRESENTATION; FAVORABLE PROGNOSIS;
D O I
10.1038/s41577-019-0257-x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This Review discusses the various ways in which B cells, plasma cells and antibodies shape the immune response in cancer. B cells can have both protumour and antitumour roles, and the authors discuss the potential of targeting these cells for therapy. Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and undergo cooperative selection, specialization and clonal expansion. Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we summarize our current knowledge of the roles of B cells and antibodies in the tumour microenvironment. Moreover, we discuss the potential of using immunoglobulin repertoires as a source of tumour-specific receptors for immunotherapy or as biomarkers to predict the efficacy of immunotherapeutic interventions.
引用
收藏
页码:294 / 307
页数:14
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