The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk

被引：18

作者：

Becker, Jessica ^{[1
,2
]}

May, Andrea ^{[3
]}

Gerges, Christian ^{[4
]}

Anders, Mario ^{[5
,6
,7
]}

Schmidt, Claudia ^{[8
]}

Veits, Lothar ^{[9
]}

Noder, Tania ^{[5
]}

Mayershofer, Rupert ^{[10
]}

Kreuser, Nicole ^{[11
]}

Manner, Hendrik ^{[12
]}

Venerito, Marino ^{[13
]}

Hofer, Jan-Hinnerk ^{[14
]}

Lyros, Orestis ^{[11
]}

Ahlbrand, Constantin J. ^{[15
]}

Arras, Michael ^{[15
]}

Hofer, Sebastian ^{[15
]}

Heinrichs, Sophie K. M. ^{[1
,2
]}

Weise, Katharina ^{[1
,2
]}

Hess, Timo ^{[1
,2
]}

Boehmer, Anne C. ^{[1
,2
]}

Kosiol, Nils ^{[1
,2
]}

Kiesslich, Ralf ^{[12
]}

Izbicki, Jakob R. ^{[16
]}

Hoelscher, Arnulf H. ^{[8
]}

Bollschweiler, Elfriede ^{[8
]}

Malfertheiner, Peter ^{[13
]}

Lang, Hauke ^{[15
]}

Moehler, Markus ^{[17
]}

Lorenz, Dietmar ^{[18
,19
]}

Ott, Katja ^{[20
,21
]}

Schmidt, Thomas ^{[21
]}

Noethen, Markus M. ^{[1
,2
]}

Hackelsberger, Andreas ^{[22
]}

Schumacher, Brigitte ^{[4
,23
,24
]}

Pech, Oliver ^{[25
,26
]}

Vashist, Yogesh ^{[16
]}

Vieth, Michael ^{[9
]}

Weismueller, Josef ^{[27
]}

Knapp, Michael ^{[28
]}

Neuhaus, Horst ^{[4
]}

Roesch, Thomas ^{[5
]}

Ell, Christian ^{[3
]}

Gockel, Ines ^{[11
]}

Schumacher, Johannes ^{[1
,2
]}

机构：

[1] Univ Bonn, Inst Human Genet, Sigmund Freud Str 25, D-53127 Bonn, Germany

[2] Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany

[3] Sana Klinikum, Dept Med 2, Offenbach, Germany

[4] Evangel Krankenhaus, Dept Internal Med 2, Dusseldorf, Germany

[5] Univ Hosp Hamburg Eppendorf, Dept Interdisciplinary Endoscopy, Hamburg, Germany

[6] Vivantes Wenckebach Kinikum, Dept Gastroenterol, Berlin, Germany

[7] Vivantes Wenckebach Kinikum, Dept Interdisciplinary Endoscopy, Berlin, Germany

[8] Univ Cologne, Dept Gen Visceral & Canc Surg, Cologne, Germany

[9] Klinikum Bayreuth, Inst Pathol, Bayreuth, Germany

[10] Gastroenterol Burgweiher, Bonn, Germany

[11] Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany

[12] HSK Hosp, Dept Internal Med 2, Wiesbaden, Germany

[13] Otto Von Guericke Univ Hosp, Dept Gastroenterol Hepatol & Infect Dis, Magdeburg, Germany

[14] Magen Darm Zentrum, Wiener Pl, Cologne, Germany

[15] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Gen Visceral & Transplant Surg, Mainz, Germany

[16] Univ Hamburg, Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Hamburg, Germany

[17] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, Mainz, Germany

[18] Sana Klinikum, Dept Gen, Offenbach, Germany

[19] Sana Klinikum, Dept Visceral Surg, Offenbach, Germany

[20] Heidelberg Univ, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany

[21] RoMed Klinikum Rosenheim, Dept Gen Visceral & Thorax Surg, Rosenheim, Germany

[22] Gastropraxis, Wiesbaden, Germany

[23] Elisabeth Hosp, Dept Internal Med, Essen, Germany

[24] Elisabeth Hosp, Dept Gastroenterol, Essen, Germany

[25] St John God Hosp, Dept Gastroenterol, Regensburg, Germany

[26] St John God Hosp, Dept Intervent Endoscopy, Regensburg, Germany

[27] Gastroenterolog Gemeinschaftspraxis, Koblenz, Germany

[28] Univ Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany

来源：

CANCER MEDICINE | 2016年 / 5卷 / 05期

关键词：

Esophageal adenocarcinoma; genetic association study; TBX5; GDF7; ALDH1A2; GENOME-WIDE ASSOCIATION; COMMON VARIANTS; LOCI; SUSCEPTIBILITY; DISEASE; DESIGN;

D O I：

10.1002/cam4.641

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.

引用

页码：888 / 891

页数：4

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