Solubility and Mixing Thermodynamic Properties of Triclabendazole in 14 Neat Solvents at Elevated Temperatures from 278.15 to 318.15 K

The triclabendazole solubility in 14 pure solvents including methanol, 1,2-dichloroethane (1,2-DCE), ethanol, n-butyl acetate, n-propanol, ethyl formate, isopropanol, n-butanol, isobutanol, ethyl acetate, acetonitrile, ethylene glycol (EG), n-propyl acetate, and n-pentyl acetate was experimentally obtained in the current research by means of the shake-flask equilibration technique at elevated temperatures from 278.15 to 318.15 K and pressure p = 101.2 kPa. With increasing temperatures, the values of the mole fraction solubility of drug triclabendazole presented a monotonic increase in tendency, and the following decreasing trend in the 14 solvents: (n-butanol, n-pentyl acetate) > n-butyl acetate > n-propyl acetate > ethyl acetate > n-propanol > ethanol > ethyl formate > isobutanol > methanol > isopropanol > 1,2-DCE > acetonitrile > EG. Two semi-empirical equations (Apelblat equation and lambda h equation) and two activity coefficient models (Wilson model and NRTL model) were utilized to associate the determined solubility data. The obtained maximum root-mean-square deviation and relative average deviation were, respectively, 2.31 x 10(-4) and 1.41 x 10(-2). In general, the Apelblat equation presented lower deviations compared with the other relationships for a specific pure solvent. Also, the mixing thermodynamic functions, reduced excess enthalpy, and infinite dilution activity coefficient were obtained from the Wilson model.