Coronary and total thoracic calcium scores predict mortality and provides pathophysiologic insights in COVID-19 patients

被引：26

作者：

Giannini, Francesco ^{[1
]}

Toselli, Marco ^{[1
]}

Palmisano, Anna ^{[2
,3
]}

Cereda, Alberto ^{[1
]}

Vignale, Davide ^{[2
,3
]}

Leone, Riccardo ^{[2
,3
]}

Nicoletti, Valeria ^{[2
,3
]}

Gnasso, Chiara ^{[2
,3
]}

Monello, Alberto ^{[4
]}

Manfrini, Marco ^{[1
]}

Khokhar, Arif ^{[1
]}

Sticchi, Alessandro ^{[1
]}

Biagi, Andrea ^{[4
]}

Turchio, Piergiorgio ^{[4
]}

Tacchetti, Carlo ^{[2
,3
]}

Landoni, Giovanni ^{[2
,3
]}

Boccia, Edda ^{[2
]}

Campo, Gianluca ^{[5
]}

Scoccia, Alessandra ^{[5
]}

Ponticelli, Francesco ^{[1
]}

Danzi, Gian Battista ^{[6
]}

Loffi, Marco ^{[6
]}

Muri, Margherita ^{[6
]}

Pontone, Gianluca ^{[7
]}

Andreini, Daniele ^{[7
]}

Mancini, Elisabetta Maria ^{[7
]}

Casella, Gianni ^{[8
]}

Iannopollo, Gianmarco ^{[8
]}

Nannini, Tommaso ^{[8
]}

Ippolito, Davide ^{[9
]}

Bellani, Giacomo ^{[9
]}

Franzesi, Camillo Talei ^{[9
]}

Patelli, Gianluigi ^{[10
]}

Besana, Francesca ^{[10
]}

Costa, Claudia ^{[10
]}

Vignali, Luigi ^{[11
]}

Benatti, Giorgio ^{[11
]}

Sverzellati, Nicola ^{[11
]}

Scarnecchia, Elisa ^{[12
]}

Lombardo, Francesco Paolo ^{[12
]}

Anastasio, Fabio ^{[12
]}

Iannaccone, Mario ^{[13
]}

Vaudano, Paolo Giacomo ^{[13
]}

Pacielli, Alberto ^{[13
]}

Baffoni, Lucio ^{[1
,14
]}

Gardi, Iljia ^{[1
]}

Cesini, Elisabetta ^{[14
]}

Sperandio, Massimiliano ^{[15
]}

Micossi, Chiara ^{[15
]}

De Carlini, Caterina Chiara ^{[16
]}

机构：

[1] GVM Care & Res Maria Cecilia Hosp, Cotignola, Italy

[2] IRCCS San Raffaele Sci Inst, Milan, MI, Italy

[3] Univ Vita Salute San Raffaele, Milan, MI, Italy

[4] Guglielmo da Saliceto Hosp, Piacenza, Italy

[5] Azienda Osped Univ Ferrara, Cona, FE, Italy

[6] Osped Cremona, Cremona, Italy

[7] Ctr Cardiol Monzino IRCCS, Milan, Italy

[8] Osped Maggiore Bologna, Bologna, Italy

[9] San Gerardo Hosp, Monza, Italy

[10] ASST Bolognini Hosp, Bergamo Est, Italy

[11] Parma Univ Hosp, Parma, Italy

[12] Eugenio Morelli Hosp, ASST Valtellina & Alto Lario, Sondalo, Italy

[13] ASL Citta Torino, San Giovanni Bosco Hosp, Turin, Italy

[14] Casa Cura Villa Pini, Civitanova Marche, Italy

[15] ICC Ist Clin Casalpalocco, Rome, Italy

[16] San L Mandic Hosp, Merate, Italy

[17] ASST Papa Giovanni XXIII, Bergamo, Italy

来源：

JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY | 2021年 / 15卷 / 05期

关键词：

COVID-19; Coronary artery; Aortic valve; Thoracic aorta; Calcification; Calcium score; In-hospital mortality; DISEASE; 2019; COVID-19; ALL-CAUSE MORTALITY; ARTERY CALCIUM; COMPUTED-TOMOGRAPHY; QUANTIFICATION; ASSOCIATION; POPULATION; EVENTS; RISK;

D O I：

10.1016/j.jcct.2021.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Coronavirus disease 2019 (COVID-19) has spread worldwide determining dramatic impacts on healthcare systems. Early identification of high-risk parameters is required in order to provide the best therapeutic approach. Coronary, thoracic aorta and aortic valve calcium can be measured from a non-gated chest computer tomography (CT) and are validated predictors of cardiovascular events and all-cause mortality. However, their prognostic role in acute systemic inflammatory diseases, such as COVID-19, has not been investigated. Objectives: The aim was to evaluate the association of coronary artery calcium and total thoracic calcium on in-hospital mortality in COVID-19 patients. Methods: 1093 consecutive patients from 16 Italian hospitals with a positive swab for COVID-19 and an admission chest CT for pneumonia severity assessment were included. At CT, coronary, aortic valve and thoracic aorta calcium were qualitatively and quantitatively evaluated separately and combined together (total thoracic calcium) by a central Core-lab blinded to patients' outcomes. Results: Non-survivors compared to survivors had higher coronary artery [Agatston (467.76 +/- 570.92 vs 206.80 +/- 424.13 mm(2), p < 0.001); Volume (487.79 +/- 565.34 vs 207.77 +/- 406.81, p < 0.001)], aortic valve [Volume (322.45 +/- 390.90 vs 98.27 +/- 250.74 mm(2), p < 0.001; Agatston 337.38 +/- 414.97 vs 111.70 +/- 282.15, p < 0.001)] and thoracic aorta [Volume (3786.71 +/- 4225.57 vs 1487.63 +/- 2973.19 mm(2), p < 0.001); Agatston (4688.82 +/- 5363.72 vs 1834.90 +/- 3761.25, p < 0.001)] calcium values. Coronary artery calcium (HR 1.308; 95% CI, 1.046-1.637, p = 0.019) and total thoracic calcium (HR 1.975; 95% CI, 1.200-3.251, p = 0.007) resulted to be independent predictors of in-hospital mortality. Conclusion Coronary, aortic valve and thoracic aortic calcium assessment on admission non-gated CT permits to stratify the COVID-19 patients in-hospital mortality risk.

引用

页码：421 / 430

页数：10

共 50 条

[31] Performance of oxygenation indices and risk scores to predict invasive mechanical ventilation and mortality in COVID-19
Alirio R. Bastidas-Goyes
Eduardo Tuta-Quintero
Maria F. Aguilar
Angélica V. Mora
Hermencia C. Aponte
Jesus M. Villamizar
Susana Galeano
Paola Mejia
Maria Muñoz
Sara Paredes
Doris Pumarejo
Maria Del Mar Barragan
BMC Pulmonary Medicine, 24
[32] Performance of oxygenation indices and risk scores to predict invasive mechanical ventilation and mortality in COVID-19
Bastidas-Goyes, Alirio R.
Tuta-Quintero, Eduardo
Aguilar, Maria F.
Mora, Angelica V.
Aponte, Hermencia C.
Villamizar, Jesus M.
Galeano, Susana
Mejia, Paola
Munoz, Maria
Paredes, Sara
Pumarejo, Doris
Barragan, Maria Del Mar
BMC PULMONARY MEDICINE, 2024, 24 (01)
[33] Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
Windradi, Choirina
Asmarawati, Tri Pudy
Rosyid, Alfian Nur
Marfiani, Erika
Mahdi, Bagus Aulia
Martani, Okla Sekar
Giarena, Giarena
Agustin, Esthiningrum Dewi
Rosandy, Milanitalia Gadys
PATHOPHYSIOLOGY, 2023, 30 (03) : 314 - 326
[34] Factors related to mortality of patients with COVID-19 who are admitted to the ICU: Prognostic mortality factors of COVID-19 patients
alvarez-Macias, Alejandro
ubeda-Iglesias, Alejandro
Macias-Seda, Juana
Gomez-Salgado, Juan
MEDICINE, 2024, 103 (21) : E38266
[35] Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19
Scoccia, Alessandra
Gallone, Guglielmo
Cereda, Alberto
Palmisano, Anna
Vignale, Davide
Leone, Riccardo
Nicoletti, Valeria
Gnasso, Chiara
Monello, Alberto
Khokhar, Arif
Sticchi, Alessandro
Biagi, Andrea
Tacchetti, Carlo
Campo, Gianluca
Rapezzi, Claudio
Ponticelli, Francesco
Danzi, Gian Battista
Loffi, Marco
Pontone, Gianluca
Andreini, Daniele
Casella, Gianni
Iannopollo, Gianmarco
Ippolito, Davide
Bellani, Giacomo
Patelli, Gianluigi
Besana, Francesca
Costa, Claudia
Vignali, Luigi
Benatti, Giorgio
Iannaccone, Mario
Vaudano, Paolo Giacomo
Pacielli, Alberto
De Carlini, Caterina Chiara
Maggiolini, Stefano
Bonaffini, Pietro Andrea
Senni, Michele
Scarnecchia, Elisa
Anastasio, Fabio
Colombo, Antonio
Ferrari, Roberto
Esposito, Antonio
Giannini, Francesco
Toselli, Marco
ATHEROSCLEROSIS, 2021, 328 : 136 - 143
[36] Evaluation of the discrimination and calibration of predictive scores of mortality in ECMO for patients with COVID-19
Huespe, Ivan Alfredo
Lockhart, Carolina
Kashyap, Rahul
Palizas Jr, Fernando
Colombo, Malena
Romero, Maria del Pilar
Prado, Eduardo
Garcia, Christian A. Casabella A.
Las Heras, Marcos
Bisso, Indalecio Carboni
ARTIFICIAL ORGANS, 2023, 47 (06) : 1007 - 1017
[37] Dyslipidaemia and mortality in COVID-19 patients: a meta-analysis
Zuin, M.
Rigatelli, G.
Bilato, C.
Cervellati, C.
Zuliani, G.
Roncon, L.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2021, 114 (06) : 390 - 397
[38] Association between number of vasopressors and mortality in COVID-19 patients
Sunnaa, Michael
Kerolos, Mina
Ruge, Max
Gill, Ahmad
Du-Fay-de-Lavallaz, Jeanne M.
Rabin, Perry
Gomez, Joanne Michelle Dumlao
Williams, Kim
Rao, Anupama
Volgman, Annabelle Santos
Marinescu, Karolina
Suboc, Tisha Marie
AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE, 2023, 34
[39] A Predicting Nomogram for Mortality in Patients With COVID-19
Pan, Deng
Cheng, Dandan
Cao, Yiwei
Hu, Chuan
Zou, Fenglin
Yu, Wencheng
Xu, Tao
FRONTIERS IN PUBLIC HEALTH, 2020, 8
[40] CT attenuation values predict liver injury in COVID-19 patients
Abdi, Negar
Ghaznavi, Hamid
EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE, 2024, 55 (01):

← 1 2 3 4 5 →