Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

被引：46

作者：

Li, L

Barrett, ADT

Beasley, DWC

机构：

[1] Univ Texas, Med Branch, Ctr Biodef & Emerging Infect Dis, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

VIROLOGY | 2005年 / 335卷 / 01期

关键词：

Flavivirus; West Nile virus; envelope protein; neutralizing epitope;

D O I：

10.1016/j.virol.2005.02.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Neutralization of flaviviruses by antibody is primarily mediated via epitopes in the viral envelope (E) protein. Comparative studies using neutralizing, monoclonal antibodies revealed differential expression of epitopes within the E protein domain III of ten naturally occurring West Nile virus strains representing major subtypes of genetic lineages 1 and 2. Residues that defined these subtype-specific determinants were identified by mutational Studies and found to be Surface exposed in the domain III structure. Mutations of residue 332 had the most significant effects on variation of domain III neutralizing epitopes among strains. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：99 / 105

页数：7

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