Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

被引：46
|
作者：
Li, L
Barrett, ADT
Beasley, DWC
机构：
[1] Univ Texas, Med Branch, Ctr Biodef & Emerging Infect Dis, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA
[2] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA
来源：
VIROLOGY | 2005年 / 335卷 / 01期
关键词：
Flavivirus; West Nile virus; envelope protein; neutralizing epitope;
D O I：
10.1016/j.virol.2005.02.011
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Neutralization of flaviviruses by antibody is primarily mediated via epitopes in the viral envelope (E) protein. Comparative studies using neutralizing, monoclonal antibodies revealed differential expression of epitopes within the E protein domain III of ten naturally occurring West Nile virus strains representing major subtypes of genetic lineages 1 and 2. Residues that defined these subtype-specific determinants were identified by mutational Studies and found to be Surface exposed in the domain III structure. Mutations of residue 332 had the most significant effects on variation of domain III neutralizing epitopes among strains. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：99 / 105
页数：7
相关论文
共 50 条
  • [21] Serological differentiation of West Nile virus- and Usutu virus-induced antibodies by envelope proteins with modified cross-reactive epitopes
    Berneck, Beatrice Sarah
    Rockstroh, Alexandra
    Barzon, Luisa
    Sinigaglia, Alessandro
    Vocale, Caterina
    Landini, Maria Paola
    Rabenau, Holger F.
    Schmidt-Chanasit, Jonas
    Ulbert, Sebastian
    TRANSBOUNDARY AND EMERGING DISEASES, 2022, 69 (05) : 2779 - 2787
  • [22] Characterization of neutralizing antibodies to West Nile virus
    Sánchez, MD
    Pierson, TC
    McAllister, D
    Hanna, SL
    Puffer, BA
    Valentine, LE
    Murtadha, MM
    Hoxie, JA
    Doms, RW
    VIROLOGY, 2005, 336 (01) : 70 - 82
  • [23] Validation of a structural comparison of the antigenic characteristics of Usutu virus and West Nile virus envelope proteins
    Nikolay, Birgit
    Fall, Gamou
    Boye, Cheikh Saad Bouh
    Sall, Amadou Alpha
    Skernd, Tim
    VIRUS RESEARCH, 2014, 189 : 87 - 91
  • [24] Cross-protection against West Nile virus in mice immunized with recombinant envelope protein domain III of Japanese encephalitis virus
    Li, S. -H.
    Li, X. -F.
    Zhao, H.
    Jiang, T.
    Deng, Y. -Q.
    Qin, E. -D.
    Qin, C. -F.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2010, 14 : S13 - S14
  • [25] A common conserved peptide harboring predicted T and B cell epitopes in domain III of envelope protein of Japanese Encephalitis Virus and West Nile Virus for potential use in epitope based vaccines
    Slathia, Parvez Singh
    Sharma, Preeti
    COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2019, 65 : 238 - 245
  • [26] Production and diagnostic application of recombinant domain III of West Nile envelope protein in Brazil
    Chavez, Juliana Helena
    dos Reis, Vinicius Pinho
    Silva, Jaqueline Raymondi
    Laure, Helen Julie
    Rosa, Jose Cesar
    Lopes da Fonseca, Benedito Antonio
    Moraes Figueiredo, Luiz Tadeu
    REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2013, 46 (01) : 97 - 99
  • [27] IDENTIFICATION OF NEUTRALIZING AND ENHANCING EPITOPES ON DENGUE VIRUS ENVELOPE PROTEIN
    Kahle, Kristen M.
    Mattia, Kimberly-Anne
    Doranz, Benjamin J.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 83 (05): : 154 - 154
  • [28] A Recombinant Influenza A Virus Expressing Domain III of West Nile Virus Induces Protective Immune Responses against Influenza and West Nile Virus
    Martina, Byron E. E.
    van den Doel, Petra
    Koraka, Penelope
    van Amerongen, Geert
    Spohn, Gunther
    Haagmans, Bart L.
    Provacia, Lisette B. V.
    Osterhaus, Albert D. M. E.
    Rimmelzwaan, Guus F.
    PLOS ONE, 2011, 6 (04):
  • [29] Differential Replication of Pathogenic and Nonpathogenic Strains of West Nile Virus within Astrocytes
    Hussmann, Katherine L.
    Samuel, Melanie A.
    Kim, Kwang S.
    Diamond, Michael S.
    Fredericksen, Brenda L.
    JOURNAL OF VIROLOGY, 2013, 87 (05) : 2814 - 2822
  • [30] Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies
    Gallichotte, Emily N.
    Young, Ellen F.
    Baric, Thomas J.
    Yount, Boyd L.
    Metz, Stefan W.
    Begley, Matthew C.
    de Silva, Aravinda M.
    Baric, Ralph S.
    MBIO, 2019, 10 (05):
12345