A concise synthesis of the dihydroxy styryllactone, 7-epi-goniodiol

被引：2

作者：

Zeng, PingLi ^{[1
]}

Wang, Dong ^{[2
]}

Zhou, Junhui ^{[1
]}

Dong, Zhibing ^{[3
]}

机构：

[1] Zhejiang Pharmaceut Coll, Sch Biol & Pharmaceut, Ningbo 315100, Zhejiang, Peoples R China

[2] Zhejiang Pharmaceut Coll, Practice & Training Ctr, Ningbo 315100, Zhejiang, Peoples R China

[3] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2016年 / 06期

基金：

中国国家自然科学基金;

关键词：

synthesis; styryllactone; 7-epi-goniodiol; goniodiol; STYRYL LACTONES; GONIOTHALAMUS; OXIDATION; ALCOHOLS;

D O I：

10.3184/174751916X14615896825798

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short and efficient stereoselective synthesis of dihydroxy styryllactone 7-epi-goniodiol has been achieved in nine steps and 20% overall yield, starting from readily available L-erythrose monoacetonide. The key steps of the synthesis involved a stereocontrolled Grignard reaction, a Stille-Gennari reaction and a one-pot acetonide deprotection-lactonisation.

引用

页码：331 / 334

页数：4

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