A concise synthesis of the dihydroxy styryllactone, 7-epi-goniodiol

被引：2
|
作者：
Zeng, PingLi [1 ]
Wang, Dong [2 ]
Zhou, Junhui [1 ]
Dong, Zhibing [3 ]
机构：
[1] Zhejiang Pharmaceut Coll, Sch Biol & Pharmaceut, Ningbo 315100, Zhejiang, Peoples R China
[2] Zhejiang Pharmaceut Coll, Practice & Training Ctr, Ningbo 315100, Zhejiang, Peoples R China
[3] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2016年 / 06期
基金：
中国国家自然科学基金;
关键词：
synthesis; styryllactone; 7-epi-goniodiol; goniodiol; STYRYL LACTONES; GONIOTHALAMUS; OXIDATION; ALCOHOLS;
D O I：
10.3184/174751916X14615896825798
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A short and efficient stereoselective synthesis of dihydroxy styryllactone 7-epi-goniodiol has been achieved in nine steps and 20% overall yield, starting from readily available L-erythrose monoacetonide. The key steps of the synthesis involved a stereocontrolled Grignard reaction, a Stille-Gennari reaction and a one-pot acetonide deprotection-lactonisation.
引用
收藏
页码：331 / 334
页数：4
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