A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine

被引：28

作者：

Banwell, Martin G. ^{[1
]}

Ma, Xinghua ^{[1
]}

Karunaratne, Ochitha P. ^{[1
]}

Willis, Anthony C. ^{[1
]}

机构：

[1] Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2010年 / 63卷 / 10期

基金：

澳大利亚研究理事会;

关键词：

ENANTIOSELECTIVE SYNTHESIS; AMARYLLIDACEAE ALKALOIDS; SECONDARY ALCOHOLS; PHENOL OXIDATION; (-)-GALANTHAMINE; GALANTHAMINE; BIOSYNTHESIS; RESOLUTION; (+/-)-GALANTHAMINE; INHIBITORS;

D O I：

10.1071/CH10201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the Eschenmoser-Claisen rearrangement reaction.

引用

页码：1437 / 1447

页数：11

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