The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament

被引：3

作者：

Katsumi, Keiichi ^{[1
,2
,21
]}

Hirai, Takashi ^{[3
,21
]}

Yoshii, Toshitaka ^{[3
,21
]}

Maki, Satoshi ^{[4
,21
]}

Mori, Kanji ^{[5
,21
]}

Nagoshi, Narihito ^{[6
,21
]}

Nishimura, Soraya ^{[6
,21
]}

Takeuchi, Kazuhiro ^{[7
,21
]}

Ushio, Shuta ^{[3
,21
]}

Furuya, Takeo ^{[4
,21
]}

Watanabe, Kei ^{[2
,21
]}

Nishida, Norihiro ^{[8
,21
]}

Watanabe, Kota ^{[6
,21
]}

Kaito, Takashi ^{[9
,21
]}

Kato, Satoshi ^{[10
,21
]}

Nagashima, Katsuya ^{[11
,21
]}

Koda, Masao ^{[11
,21
]}

Ito, Kenyu ^{[12
,21
]}

Imagama, Shiro ^{[12
,21
]}

Matsuoka, Yuji ^{[13
,21
]}

Wada, Kanichiro ^{[14
,21
]}

Kimura, Atsushi ^{[15
,21
]}

Ohba, Tetsuro ^{[16
,21
]}

Katoh, Hiroyuki ^{[17
,21
]}

Matsuyama, Yukihiro ^{[18
,21
]}

Ozawa, Hiroshi ^{[19
,21
]}

Haro, Hirotaka ^{[16
,21
]}

Takeshita, Katsushi ^{[15
,21
]}

Watanabe, Masahiko ^{[17
,21
]}

Matsumoto, Morio ^{[6
,21
]}

Nakamura, Masaya ^{[6
,21
]}

Yamazaki, Masashi ^{[11
,21
]}

Okawa, Atsushi ^{[3
,21
]}

Kawaguchi, Yoshiharu ^{[20
,21
]}

机构：

[1] Niigata Cent Hosp, Dept Orthoped Surg, Spine Ctr, Chuo Ku, 1-18 Shinkocho, Niigata, Niigata 9508556, Japan

[2] Niigata Univ, Dept Orthoped Surg, Med & Dent Gen Hosp, Chuo Ku, 1-757 Asahimachidori, Niigata, Niigata 9518510, Japan

[3] Tokyo Med & Dent Univ, Dept Orthoped Surg, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan

[4] Chiba Univ, Grad Sch Med, Dept Orthopaed Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2600856, Japan

[5] Shiga Univ Med Sci, Dept Orthopaed Surg, Otsu, Shiga 5202192, Japan

[6] Keio Univ, Sch Med, Dept Orthopaed Surg, Shinjuku Ku, 35 Shinanomachi, Tokyo, Japan

[7] Natl Hosp Org Okayama Med Ctr, Dept Orthoped Surg, 1711-1 Tamasu, Okayama, Okayama, Japan

[8] Yamaguchi Univ, Dept Orthopaed Surg, Grad Sch Med, 1-1-1 Minamikogushi, Ube, Yamaguchi 7558505, Japan

[9] Osaka Univ, Dept Orthopaed Surg, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[10] Kanazawa Univ, Grad Sch Med Sci, Dept Orthoped Surg, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan

[11] Univ Tsukuba, Dept Orthopaed Surg, Fac Med, 2-1-1 Amakubo, Tsukuba, Ibaraki 3058576, Japan

[12] Nagoya Univ, Grad Sch Med, Dept Orthoped Surg, Showa Ku, 65 Tsurumaicho, Nagoya, Aichi 4660065, Japan

[13] Tokyo Med Univ, Dept Orthoped Surg, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan

[14] Hirosaki Univ, Dept Orthopaed Surg, Grad Sch Med, 53 Honcho, Hirosaki, Aomori 0368203, Japan

[15] Jichi Med Univ, Dept Orthopaed Surg, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan

[16] Univ Yamanashi, Dept Orthoped Surg, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan

[17] Tokai Univ, Dept Orthopaed Surg, Surg Sci, Sch Med, 143 Shimokasuya, Isehara, Kanagawa 2591143, Japan

[18] Hamamatsu Univ Sch Med, Dept Orthoped Surg, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313125, Japan

[19] Tohoku Med & Pharmaceut Univ, Dept Orthopaed Surg, Miyagino Ku, 1-12-1 Fukumuro, Sendai, Miyagi 9838512, Japan

[20] Toyama Univ, Dept Orthoped Surg, Fac Med, 2630 Sugitani, Toyama, Toyama 9300194, Japan

[21] Japanese Org Study Ossificat Spinal Ligament JOSL, Tokyo, Japan

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

EVALUATION QUESTIONNAIRE JOACMEQ; SPONDYLOTIC MYELOPATHY; OUTCOME MEASURE; RANGE; LAMINOPLASTY; MOTION; ALIGNMENT;

D O I：

10.1038/s41598-021-93602-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ossification of the posterior longitudinal ligament (OPLL) is a progressive disease. The bridging of ossified lesions to the vertebral body gradually increases, thereby decreasing the mobility of the cervical spine; thus, cervical spine function may decrease over time. However, cervical spine function in patients with cervical OPLL has not been evaluated in large prospective studies. Therefore, we conducted a prospective multicenter study to clarify whether ossification spread can influence cervical spine function and quality of life (QOL) in patients with cervical OPLL. In total, 238 patients (162 men, 76 women; mean age, 63.9 years) were enrolled from 16 institutions. Each patient underwent whole spine computed tomography and was evaluated for cervical spine function and QOL using the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). In the multivariate regression analysis, a higher neck VAS score and a larger number of bridge formations of OPLL in the whole spine were significant predictors of adverse outcomes related to cervical spine function. This is the first prospective multicenter study to reveal the impact of ossification spread on cervical spine function. These findings are important to understand the natural course of OPLL and can serve as controls when evaluating postoperative cervical spine function.

引用

页数：9

共 50 条

[1] The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament
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