Asthma: Chronopharmacotherapy and the molecular clock

被引：43

作者：

Burioka, Naoto ^{[1
,2
]}

Fukuoka, Yasushi ^{[2
]}

Koyanagi, Satoru ^{[3
]}

Miyata, Masanori ^{[4
]}

Takata, Miyako ^{[2
]}

Chikumi, Hiroki ^{[2
]}

Takane, Hiroshi ^{[5
]}

Watanabe, Masanari ^{[2
]}

Endo, Masahiro ^{[2
]}

Sako, Takanori ^{[4
]}

Suyama, Hisashi ^{[2
]}

Ohdo, Shigehiro ^{[3
]}

Shimizu, Eiji ^{[2
]}

机构：

[1] Tottori Univ, Fac Med, Dept Pathobiol Sci & Technol, Div Sch Hlth Sci, Yonago, Tottori 6838503, Japan

[2] Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, Yonago, Tottori 6838504, Japan

[3] Kyushu Univ, Fac Pharmaceut Sci, Dept Medicopharmaceut Sci, Div Clin Pharm,Higashi Ku, Fukuoka 8128582, Japan

[4] Obase Hosp, Dept Internal Med, Fukuoka 8000344, Japan

[5] Tottori Univ, Fac Med, Dept Pharmacol, Yonago, Tottori 6838504, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 9-10期

关键词：

beta(2)-adrenoceptor agonist; Bronchial asthma; Chronopharmacology; Chronotherapy; Circadian rhythm; Clock gene; Glucocorticoid; Hypoxia; Theophylline; SUSTAINED-RELEASE THEOPHYLLINE; BLOOD MONONUCLEAR-CELLS; OBSTRUCTIVE SLEEP-APNEA; PERIPHERAL CIRCADIAN OSCILLATORS; LEUKOTRIENE-RECEPTOR ANTAGONIST; MODERATE PERSISTENT ASTHMA; MESSENGER-RNA EXPRESSION; PEAK EXPIRATORY FLOW; NOCTURNAL ASTHMA; GENE-EXPRESSION;

D O I：

10.1016/j.addr.2010.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bronchial asthma is characterized by chronic airways inflammation and reversible airflow limitation. In patients with asthma, symptoms generally worsen during the early hours of the morning, and pulmonary function often deteriorates at the same time, suggesting a role for chronopharmacotherapy. Several drugs for asthma have been developed based on chronopharmacology. Most medications employed for the chronotherapy of asthma are administered once at night with the goal of preventing chronic airway inflammation or development of airflow limitation. In addition to bronchodilators, the inhaled glucocorticosteroid ciclesonide is now available with once-daily dosing, which also improves patients' compliance. Numerous investigations have demonstrated the usefulness of chronotherapy for asthma, especially for patients with nocturnal asthma. This review focuses on chronotherapy of asthma, and also provides a molecular biological explanation for the influence of asthma medications on the clock genes. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：946 / 955

页数：10

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