Delivering a hydrophobic anticancer drug for photodynamic therapy by amorphous formulation

被引：8

作者：

Zhou, Lin ^{[2
]}

Wang, Wei ^{[1
]}

Feng, Yuying ^{[1
]}

Wei, Shaohua ^{[1
]}

Zhou, Jiahong ^{[1
]}

Yu, Boyang ^{[2
]}

Shen, Jian ^{[1
]}

机构：

[1] Nanjing Normal Univ, Anal & Testing Ctr, Jiangsu Key Lab Biofunct Mat, Nanjing 210046, Peoples R China

[2] China Pharmaceut Univ, TCM, Dept Complex Prescript, Nanjing 211198, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Amorphous formulation; Hypocrellin A; Photodynamic therapy; Drug delivery system; HYPOCRELLIN-B; NANOPARTICLES; NANOSUSPENSIONS; COMPLEX; SIZE;

D O I：

10.1016/j.bmcl.2010.08.132

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An amorphous formulation of hypocrellin A for photodynamic therapy is reported which can provide stable aqueous dispersion of such hydrophobic photosensitizers. In vitro studies have demonstrated the active uptake of amorphous formulation of hypocrellin A into the mitochondria of tumor cells. Compared with Tween-80 micelle embedded hypocrellin A, low dark-toxicity but similar light-toxicity of the amorphous one to drug impregnated tumor cells was observed. Thus, the potential of using amorphous formulation of hypocrellin A as drug delivery system for photodynamic therapy has been demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6172 / 6174

页数：3

共 29 条

[1] Effects of sonication on the size and crystallinity of stable zwitterionic organic nanoparticles formed by reprecipitation in water [J].

Al-Kaysi, RO ;

Müller, AM ;

Ahn, TS ;

Lee, S ;

Bardeen, CJ .

LANGMUIR, 2005, 21 (17) :7990-7994

[2] New method for delivering a hydrophobic drug for photodynamic therapy using pure nanocrystal form of the drug [J].

Baba, Koichi ;

Pudavar, Haridas E. ;

Roy, Indrajit ;

Ohulchanskyy, Tymish Y. ;

Chen, Yihui ;

Pandey, Ravindra K. ;

Prasad, Paras N. .

MOLECULAR PHARMACEUTICS, 2007, 4 (02) :289-297

[3] Nanoparticles as vehicles for delivery of photodynamic therapy agents [J].

Bechet, Denise ;

Couleaud, Pierre ;

Frochot, Celine ;

Viriot, Marie-Laure ;

Guillemin, Francois ;

Barberi-Heyob, Muriel .

TRENDS IN BIOTECHNOLOGY, 2008, 26 (11) :612-621

[4] Curcurnin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells [J].

Cao, Jun ;

Liu, Yong ;

Jia, Li ;

Zhou, Hui-Min ;

Kong, Ying ;

Yang, Guang ;

Jiang, Li-Ping ;

Li, Qiu-Juan ;

Zhong, Lai-Fu .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 43 (06) :968-975

[5] A novel approach to a bifunctional photosensitizer for tumor imaging and phototherapy [J].

Chen, YH ;

Gryshuk, A ;

Achilefu, S ;

Ohulchansky, T ;

Potter, W ;

Zhong, TX ;

Morgan, J ;

Chance, B ;

Prasad, PN ;

Henderson, BW ;

Oseroff, A ;

Pandey, RK .

BIOCONJUGATE CHEMISTRY, 2005, 16 (05) :1264-1274

[6] Amorphous Compositions Using Concentration Enhancing Polymers for Improved Bioavailability of Itraconazole [J].

DiNunzio, James C. ;

Miller, Dave A. ;

Yang, Wei ;

McGinity, James W. ;

Williams, Robert O., III .

MOLECULAR PHARMACEUTICS, 2008, 5 (06) :968-980

[7] Photodynamic therapy for cancer [J].

Dolmans, DEJGJ ;

Fukumura, D ;

Jain, RK .

NATURE REVIEWS CANCER, 2003, 3 (05) :380-387

[8] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

[9] Bioeliminable Nanohydrogels for Drug Delivery [J].

Gao, De ;

Xu, Hao ;

Philbert, Martin A. ;

Kopelman, Raoul .

NANO LETTERS, 2008, 8 (10) :3320-3324

[10] Synthesis of a new water-soluble phototherapeutic sensitizer from hypocrellin B with enhanced red absorption [J].

He, YY ;

An, JY ;

Jiang, LJ .

DYES AND PIGMENTS, 1999, 41 (1-2) :93-100

← 1 2 3 →