Role of shelterin in cancer and aging

被引：122
作者：
Martinez, Paula [1 ]
Blasco, Maria A. [1 ]
机构：
[1] Spanish Natl Canc Ctr CNIO, Mol Oncol Program, Telomeres & Telomerase Grp, E-28029 Madrid, Spain
来源：
AGING CELL | 2010年 / 9卷 / 05期
基金：
欧洲研究理事会;
关键词：
aging; cancer; mouse models; shelterin; telomerase; telomeres; HUMAN TELOMERIC PROTEINS; GENOME-WIDE ASSOCIATION; DNA-DAMAGE RESPONSE; POLY(ADP-RIBOSE) POLYMERASE; DYSFUNCTIONAL TELOMERES; LIFE-SPAN; IN-VIVO; HOMOLOGOUS RECOMBINATION; REVERSE-TRANSCRIPTASE; SUSCEPTIBILITY LOCI;
D O I：
10.1111/j.1474-9726.2010.00596.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
P>Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence bound by a specialized six-protein complex known as shelterin, which has fundamental roles in the regulation of telomere length and telomere capping. In the past, the study of mice genetically modified for telomerase components has been instrumental to demonstrate the role of telomere length in cancer and aging. Recent studies using genetically modified mice for shelterin proteins have highlighted an equally important role of telomere-bound proteins in cancer and aging, even in the presence of proficient telomerase activity and normal telomere length. In this review, we will focus on recent findings, suggesting a role of shelterin components in cancer and aging.
引用
收藏
页码：653 / 666
页数：14
相关论文
共 141 条
[1]   Targeting assay to study the cis functions of human telomeric proteins:: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2 [J].
Ancelin, K ;
Brunori, M ;
Bauwens, S ;
Koering, CE ;
Brun, C ;
Ricoul, M ;
Pommier, JP ;
Sabatier, L ;
Gilson, E .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (10) :3474-3487
[2]   Telomerase mutations in families with idiopathic pulmonary fibrosis [J].
Armanios, Mary Y. ;
Chen, Julian J. -L. ;
Cogan, Joy D. ;
Alder, Jonathan K. ;
Ingersoll, Roxann G. ;
Markin, Cheryl ;
Lawson, William E. ;
Xie, Mingyi ;
Vulto, Irma ;
Phillips, John A., III ;
Lansdorp, Peter M. ;
Greider, Carol W. ;
Loyd, James E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) :1317-1326
[3]   Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].
Artandi, SE ;
Chang, S ;
Lee, SL ;
Alson, S ;
Gottlieb, GJ ;
Chin, L ;
DePinho, RA .
NATURE, 2000, 406 (6796) :641-645
[4]   Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].
Artandi, SE ;
Alson, S ;
Tietze, MK ;
Sharpless, NE ;
Ye, S ;
Greenberg, RA ;
Castrillon, DH ;
Horner, JW ;
Weiler, SR ;
Carrasco, RD ;
DePinho, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196
[5]   A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends [J].
Bae, Nancy S. ;
Baumann, Peter .
MOLECULAR CELL, 2007, 26 (03) :323-334
[6]   Pot1, the putative telomere end-binding protein in fission yeast and humans [J].
Baumann, P ;
Cech, TR .
SCIENCE, 2001, 292 (5519) :1171-1175
[7]   p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice [J].
Begus-Nahrmann, Yvonne ;
Lechel, Andre ;
Obenauf, Anna C. ;
Nalapareddy, Kodandaramireddy ;
Peit, Elvira ;
Hoffmann, Eva ;
Schlaudraff, Falk ;
Liss, Birgit ;
Schirmacher, Peter ;
Kestler, Hans ;
Danenberg, Esther ;
Barker, Nick ;
Clevers, Hans ;
Speicher, Michael R. ;
Rudolph, K. Lenhard .
NATURE GENETICS, 2009, 41 (10) :1138-U125
[8]   TRF1 binds a bipartite telomeric site with extreme spatial flexibility [J].
Bianchi, A ;
Stansel, RM ;
Fairall, L ;
Griffith, JD ;
Rhodes, D ;
de Lange, T .
EMBO JOURNAL, 1999, 18 (20) :5735-5744
[9]   Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis [J].
Blanco, Raquel ;
Munoz, Purificacion ;
Flores, Juana M. ;
Klatt, Peter ;
Blasco, Maria A. .
GENES & DEVELOPMENT, 2007, 21 (02) :206-220
[10]   Telomeres and human disease: Ageing, cancer and beyond [J].
Blasco, MA .
NATURE REVIEWS GENETICS, 2005, 6 (08) :611-622
12345678910