EXPLOITING IRON-BINDING PROTEINS FOR DRUG DELIVERY

被引：14
作者：
Bialasek, M. [1 ]
Kubiak, M. [1 ]
Gorczak, M. [1 ]
Braniewska, A. [2 ]
Kucharzewska-Siembieda, P. [1 ]
Krol, M. [1 ]
Taciak, B. [1 ]
机构：
[1] Warsaw Univ Life Sci SGGW, Inst Biol, Dept Canc Biol, Warsaw, Poland
[2] Med Univ Warsaw, Ctr Biostruct Res, Dept Immunol, Warsaw, Poland
来源：
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2019年 / 70卷 / 05期
基金：
欧洲研究理事会;
关键词：
drug delivery; iron-binding proteins; transferrin; ferritin; hemoglobin; reactive oxygen species; anticancer therapy; CELL-SURFACE GLYCOPROTEIN; HUMAN-SERUM TRANSFERRIN; BLOOD-BRAIN-BARRIER; FERRITIN NANOCAGES; SCAVENGER RECEPTOR; THERAPEUTIC AGENTS; APOFERRITIN CAVITY; TARGETED DELIVERY; MOLECULAR-CLONING; ANTICANCER DRUGS;
D O I：
10.26402/jpp.2019.5.03
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Currently, many therapies fail due to an insufficient drug dose reaching the target site and high systemic toxicity. Protein-based drug delivery systems that allow an increase in drug concentration at a specific location in the body or predominantly target malignant cells are promising technologies. Due to the high need for iron in many disorders including various types of cancer, iron-binding proteins: transferrin, ferritin and hemoglobin, are a promising tool as drug carriers. In this review we summarize the characteristics of human iron-binding proteins and present their use in targeted drug delivery strategies.
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页数：11
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