The threat of avian influenza A (H5N1). Part I: epidemiologic concerns and virulence determinants

被引：40

作者：

Cinatl, Jindrich, Jr. ^{[1
]}

Michaelis, Martin ^{[1
]}

Doerr, Hans W. ^{[1
]}

机构：

[1] Hosp Johann Wolfgang Goethe Univ, Inst Med Virol, D-60596 Frankfurt, Germany

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2007年 / 196卷 / 04期

关键词：

D O I：

10.1007/s00430-007-0042-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This first part concentrates on epidemiologic concerns and virulence determinants. H5N1 spread over the world and caused a series of fowl pest outbreaks. Significant human-to-human transmissions have not been observed yet. Mutations that make the virus more compatible with human-to-human transmission may occur at any time. Nevertheless, no one can currently predict with certainty whether H5N1 will become a human pandemic virus.

引用

页码：181 / 190

页数：10

共 72 条

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