Effect of primate bone marrow stromal cells on survival and neurite outgrowth

被引：4

作者：

Kim, Keung Nyun ^{[1
]}

Guest, James D. ^{[3
]}

Oh, Jin Soo ^{[1
,2
]}

Pennant, William A. ^{[1
]}

Yoon, Do Heum ^{[1
,2
]}

Ha, Yoon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Neurol Surg, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul, South Korea

[3] Univ Miami, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL USA

来源：

NEUROREPORT | 2010年 / 21卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

bone marrow stromal cell; dorsal root ganglia; in vitro; neurite outgrowth; neuronal survival; nonhuman primate; ENDOTHELIAL GROWTH-FACTOR; SPINAL-CORD-INJURY; COLONY-STIMULATING FACTOR; SYMPATHETIC NEURONS; FUNCTIONAL RECOVERY; MESSENGER-RNA; EXPRESSION; INTERLEUKIN-6; RECEPTOR; TISSUE;

D O I：

10.1097/WNR.0b013e32833da3a6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We tested whether bone marrow stromal cells (BMSCs) could enhance the survival and neurite growth of dorsal root ganglia (DRG) through substrate effects or secreted factors. Our results showed that in DRG with BMSCs and BMSC-conditioned media cultures compared with DRG-fibroblast cultures, there was a significant increase in the number and length of, area covered by, and number of cells with definite neurites. In cytokine assays with conditioned media, vascular endothelial growth factor, granulocyte macrophage colony-stimulating factor, and IL-6 secreted by BMSCs may contribute to observed neurotrophic effects. These findings indicate that BMSCs of adult Macaca fascicularis increased neuronal survival and promoted neurite outgrowth of DRG by means of secretory factors. NeuroReport 21: 877-881 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：877 / 881

页数：5

共 25 条

[1] Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats [J].

Ankeny, DP ;

McTigue, DM ;

Jakeman, LB .

EXPERIMENTAL NEUROLOGY, 2004, 190 (01) :17-31

[2] Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor [J].

Armitage, JO .

BLOOD, 1998, 92 (12) :4491-4508

[3] Antiangiogenic tumour therapy: will it work? [J].

Augustin, HG .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1998, 19 (06) :216-222

[4] Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages [J].

Bouhy, Delphine ;

Malgrange, Brigitte ;

Multon, Sylvie ;

Poirrier, Anne-Lise ;

Scholtes, Felix ;

Schoenen, Jean ;

Franzen, Rachelle .

FASEB JOURNAL, 2006, 20 (08) :1239-+

[5] Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: Growth factor production [J].

Chen, XG ;

Katakowski, M ;

Li, Y ;

Lu, DY ;

Wang, L ;

Zhang, LJ ;

Chen, JL ;

Xu, YX ;

Gautam, S ;

Mahmood, A ;

Chopp, M .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 69 (05) :687-691

[6] Treatment of neural injury with marrow stromal cells [J].

Chopp, M ;

Li, Y .

LANCET NEUROLOGY, 2002, 1 (02) :92-100

[7] Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation [J].

Chopp, M ;

Zhang, XH ;

Li, Y ;

Wang, L ;

Chen, JL ;

Lu, DY ;

Lu, M ;

Rosenblum, M .

NEUROREPORT, 2000, 11 (13) :3001-3005

[8] Mesenchymal stem cells: Biology and potential clinical uses [J].

Deans, RJ ;

Moseley, AB .

EXPERIMENTAL HEMATOLOGY, 2000, 28 (08) :875-884

[9] Neurotrophins and their receptors in nerve injury and repair [J].

Ebadi, M ;

Bashir, RM ;

Heidrick, ML ;

Hamada, FM ;

ElRefaey, H ;

Hamed, A ;

Helal, G ;

Baxi, MD ;

Cerutis, DR ;

Lassi, NK .

NEUROCHEMISTRY INTERNATIONAL, 1997, 30 (4-5) :347-374

[10] Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro [J].

Gavazzi, I ;

Kumar, RDC ;

McMahon, SB ;

Cohen, J .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (10) :3405-3414

← 1 2 3 →