Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides

被引：174

作者：

Liao, Jia-Yu ^{[1
]}

Shao, Pan-Lin ^{[1
,2
]}

Zhao, Yu ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Chongqing Univ, Innovat Drug Res Ctr, Chongqing 401331, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

ASYMMETRIC ALDOL REACTION; CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEX; QUATERNARY CARBON STEREOCENTERS; MANNICH-TYPE REACTION; UMPOLUNG ADDITION; MULTICOMPONENT REACTIONS; ENANTIOSELECTIVE CONSTRUCTION; OLIGOSUBSTITUTED PYRROLES; REGIOSELECTIVE SYNTHESIS; ALPHA-ISOCYANOACETATES;

D O I：

10.1021/ja511895q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cyclization of allenoates with activated isocyanides was reported for the first time. While Ag catalysis led to an unprecedented enantioselective synthesis of 3H pyrroles, a simple procedure using PPh3 produced a wide range of polysubstituted 1H pyrroles with high efficiency.

引用

页码：628 / 631

页数：4

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