Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides

被引：174
作者：
Liao, Jia-Yu [1 ]
Shao, Pan-Lin [1 ,2 ]
Zhao, Yu [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[2] Chongqing Univ, Innovat Drug Res Ctr, Chongqing 401331, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
ASYMMETRIC ALDOL REACTION; CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEX; QUATERNARY CARBON STEREOCENTERS; MANNICH-TYPE REACTION; UMPOLUNG ADDITION; MULTICOMPONENT REACTIONS; ENANTIOSELECTIVE CONSTRUCTION; OLIGOSUBSTITUTED PYRROLES; REGIOSELECTIVE SYNTHESIS; ALPHA-ISOCYANOACETATES;
D O I：
10.1021/ja511895q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cyclization of allenoates with activated isocyanides was reported for the first time. While Ag catalysis led to an unprecedented enantioselective synthesis of 3H pyrroles, a simple procedure using PPh3 produced a wide range of polysubstituted 1H pyrroles with high efficiency.
引用
收藏
页码：628 / 631
页数：4
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