Enantioanalysis of (-)Butaclamol Using Vancomycin and Teicoplanin as Chiral Selectors

被引：3

作者：

van Staden, Raluca-Ioana Stefan ^{[1
,2
]}

Nhlapo, Nontete Suzan ^{[1
,2
]}

van Staden, Jacobus Frederick ^{[1
,2
]}

Aboul-Enein, Hassan Y. ^{[3
]}

机构：

[1] Natl Inst Res Electrochem & Condensed Matter, Lab Electrochem, Bucharest 060021, Romania

[2] Natl Inst Res Electrochem & Condensed Matter, PATLAB Bucharest, Bucharest 060021, Romania

[3] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceutcial & Med Chem Dept, Cairo 12311, Egypt

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2010年 / 13卷 / 08期

关键词：

Enantioselective; potentiometric membrane electrode; (-) butaclamol; vancomycin; teicoplanin; POTENTIOMETRIC MEMBRANE ELECTRODES; MACROCYCLIC ANTIBIOTICS; LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; HUMAN PLASMA; ENANTIOMERS; BUTACLAMOL; SEPARATION; DRUGS; ACID;

D O I：

10.2174/138620710791920301

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.

引用

页码：690 / 693

页数：4

共 50 条

[41] INVITRO ACTIVITY OF VANCOMYCIN AND TEICOPLANIN ON GRAM-POSITIVE COCCI
BEZIAN, MC
RIBOU, G
MASQUELIER, B
PATHOLOGIE BIOLOGIE, 1992, 40 (05): : 461 - 465
[42] Enantioanalysis of S-Ketoprofen Using Enantioselective, Potentiometric Membrane Electrodes
Stefan-van Staden, Raluca-Ioana
Nhlapo, Nontete Suzan
van Staden, Jacobus Frederick
Aboul-Enein, Hassan Y.
ANALYTICAL LETTERS, 2009, 42 (05) : 764 - 774
[43] Enantioseparation of semisynthetic ergot alkaloids on vancomycin and teicoplanin stationary phases
Tesarová, E
Záruba, K
Flieger, M
JOURNAL OF CHROMATOGRAPHY A, 1999, 844 (1-2) : 137 - 147
[44] Effect of molecular structure of tartrates on chiral recognition of tartrate-boric acid complex chiral selectors in chiral microemulsion electrokinetic chromatography
Hu, Shao-Qiang
Chen, Yong-Lei
Zhu, Hua-Dong
Shi, Hai-Jun
Yan, Na
Chen, Xing-Guo
JOURNAL OF CHROMATOGRAPHY A, 2010, 1217 (34) : 5529 - 5535
[45] Evaluation and Comparison of m-Tolyl Isocyanate Teicoplanin and Teicoplanin Chiral Stationary Phase
Shen Baochun
Yuan Jianyong
Xu Beijia
Xu Xiuzhu
ACTA CHIMICA SINICA, 2009, 67 (17) : 2005 - 2012
[46] Recent advances in enantioseparation by capillary electrophoresis using antibiotics and polysaccharides as chiral selectors A review
Du, Yingxiang
Chen, Bin
CHIMICA OGGI-CHEMISTRY TODAY, 2010, 28 (05): : 37 - 42
[47] Enantioseparation of (±)-Terbutaline by Ligand Exchange Using L-Amino Acids as Chiral Selectors
Singh, Manisha
Singh, Sonika
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2018, 31 (05) : 361 - 365
[48] Comparative analysis of the full set of methylated β-cyclodextrins as chiral selectors in capillary electrophoresis
Varga, Erzsebet
Benkoyics, Gabor
Darcsi, Andras
Varnai, Bianka
Sohajda, Tamas
Malanga, Milo
Beni, Szabolcs
ELECTROPHORESIS, 2019, 40 (21) : 2789 - 2798
[49] Enantioanalysis of Tertatolol in Plasma and Pharmaceutical Formulations with Immobilized Polysaccharide-Derived HPLC Chiral Column at Nano-detection Level
Hefnawy, Mohamed
Al-Majed, Abdulrhman
Al-Suwailem, Aymen
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2009, 32 (13) : 1934 - 1952
[50] Characterisation of the selective binding of antibiotics vancomycin and teicoplanin by the VanS receptor regulating type A vancomycin resistance in the enterococci
Hughes, C. S.
Longo, E.
Phillips-Jones, M. K.
Hussain, R.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2017, 1861 (08): : 1951 - 1959

← 1 2 3 4 5 →