Enantioanalysis of (-)Butaclamol Using Vancomycin and Teicoplanin as Chiral Selectors

被引：3

作者：

van Staden, Raluca-Ioana Stefan ^{[1
,2
]}

Nhlapo, Nontete Suzan ^{[1
,2
]}

van Staden, Jacobus Frederick ^{[1
,2
]}

Aboul-Enein, Hassan Y. ^{[3
]}

机构：

[1] Natl Inst Res Electrochem & Condensed Matter, Lab Electrochem, Bucharest 060021, Romania

[2] Natl Inst Res Electrochem & Condensed Matter, PATLAB Bucharest, Bucharest 060021, Romania

[3] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceutcial & Med Chem Dept, Cairo 12311, Egypt

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2010年 / 13卷 / 08期

关键词：

Enantioselective; potentiometric membrane electrode; (-) butaclamol; vancomycin; teicoplanin; POTENTIOMETRIC MEMBRANE ELECTRODES; MACROCYCLIC ANTIBIOTICS; LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; HUMAN PLASMA; ENANTIOMERS; BUTACLAMOL; SEPARATION; DRUGS; ACID;

D O I：

10.2174/138620710791920301

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.

引用

页码：690 / 693

页数：4

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