Constituents of red yeast rice, a traditional Chinese food and medicine

被引:347
作者
Ma, JY [1 ]
Li, YG [1 ]
Ye, Q [1 ]
Li, J [1 ]
Hua, YJ [1 ]
Ju, DJ [1 ]
Zhang, DC [1 ]
Cooper, R [1 ]
Chang, M [1 ]
机构
[1] Pharmanex Inc, Brisbane, CA 94005 USA
关键词
red yeast rice; traditional Chinese medicine; monacolins; constituents;
D O I
10.1021/jf000338c
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Detailed analyses were undertaken of the natural constituents of red yeast rice, a traditional Chinese medicine and food known for centuries to improve blood circulation. Preparation of red yeast rice following ancient methods by fermenting the fungal strain Monascus purpureus Went on moist and sterile rice indicated the presence of a group of metabolites belonging to the monacolin family of polyketides, together with fatty acids, and trace elements. The presence of these compounds may explain in part the cholesterol-lowering ability associated with this traditional Chinese food.
引用
收藏
页码:5220 / 5225
页数:6
相关论文
共 41 条
[1]   DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS-TERREUS [J].
ALBERSSCHONBERG, G ;
JOSHUA, H ;
LOPEZ, MB ;
HENSENS, OD ;
SPRINGER, JP ;
CHEN, J ;
OSTROVE, S ;
HOFFMAN, CH ;
ALBERTS, AW ;
PATCHETT, AA .
JOURNAL OF ANTIBIOTICS, 1981, 34 (05) :507-512
[2]   MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].
ALBERTS, AW ;
CHEN, J ;
KURON, G ;
HUNT, V ;
HUFF, J ;
HOFFMAN, C ;
ROTHROCK, J ;
LOPEZ, M ;
JOSHUA, H ;
HARRIS, E ;
PATCHETT, A ;
MONAGHAN, R ;
CURRIE, S ;
STAPLEY, E ;
ALBERSSCHONBERG, G ;
HENSENS, O ;
HIRSHFIELD, J ;
HOOGSTEEN, K ;
LIESCH, J ;
SPRINGER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961
[3]  
[Anonymous], 1982, 27072706381 GB CHIN
[4]  
[Anonymous], CHEM PHARM B
[5]  
[Anonymous], J TRADIT MED
[6]   Enantioselective total synthesis of (+)-6-epi-mevinolin and its analogs. Efficient construction of the hexahydronaphthalene moiety by high pressure-promoted intramolecular Diels-Alder reaction of (R,2Z,8E,10E)-1-[(tert-butyldimethylsilyl)oxy]-6-methyl-2,8,10-dodecatrien-4-one [J].
Araki, Y ;
Konoike, T .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (16) :5299-5309
[7]   HYDROXYMETHYLGLUTARYL-COA REDUCTASE, A KEY ENZYME IN PHYTOSTEROL SYNTHESIS [J].
BACH, TJ .
LIPIDS, 1986, 21 (01) :82-88
[8]   CONVENIENT 2-STEP STEREOSPECIFIC HYDROXY-SUBSTITUTION WITH RETENTION IN BETA-HYDROXY-DELTA-LACTONES - 4(R)-HETEROSUBSTITUTED MEVINOLIN AND 4(R)-ANALOGS [J].
BARTMANN, W ;
BECK, G ;
GRANZER, E ;
JENDRALLA, H ;
VONKEREKJARTO, B ;
WESS, G .
TETRAHEDRON LETTERS, 1986, 27 (39) :4709-4712
[9]  
Bensky D, 1986, CHINESE HERBAL MED M
[10]   PIGMENTS OF MONASCUS [J].
BLANC, PJ ;
LORET, MO ;
SANTERRE, AL ;
PAREILLEUX, A ;
PROME, D ;
PROME, JC ;
LAUSSAC, JP ;
GOMA, G .
JOURNAL OF FOOD SCIENCE, 1994, 59 (04) :862-865