αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading

被引：0

作者：

Willey, Jeffrey S. ^{[1
]}

Aunon-Chancellor, Serena ^{[2
]}

Miles, Lauren A. ^{[3
]}

Moore, Joseph E. ^{[1
]}

Mao, Xiao W. ^{[4
]}

Wallace, Robert W. ^{[2
]}

Foy, Matthew C. ^{[5
]}

机构：

[1] Wake Forest Sch Med, Dept Radiat Oncol, Sect Radiat Biol, Winston Salem, NC 27101 USA

[2] Louisiana State Univ, Dept Internal Med, Med Ctr, Baton Rouge, LA 70803 USA

[3] Wake Forest Sch Med, Dept Nephrol, Winston Salem, NC 27101 USA

[4] Loma Linda Univ, Dept Basic Sci, Loma Linda, CA 92350 USA

[5] Louisiana State Univ, Med Ctr, Div Nephrol, Dept Internal Med, Baton Rouge, LA 70803 USA

来源：

NPJ MICROGRAVITY | 2022年 / 8卷 / 01期

关键词：

EXERCISE; BONE; PHOSPHATE; PROTEIN;

D O I：

10.1038/s41526-022-00203-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alpha(alpha)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma alpha Klotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma alpha Klotho: plasma alpha Klotho recovered with exercise after HU.

引用

页数：3

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