cDNA cloning of rat cardiotrophin-1 (CT-1): Augmented expression of CT-1 gene in ventricle of genetically hypertensive rats

被引：51

作者：

Ishikawa, M ^{[1
]}

Saito, Y ^{[1
]}

Miyamoto, Y ^{[1
]}

Kuwahara, K ^{[1
]}

Ogawa, E ^{[1
]}

Nakagawa, O ^{[1
]}

Harada, M ^{[1
]}

Masuda, I ^{[1
]}

Nakao, K ^{[1
]}

机构：

[1] KYOTO UNIV,GRAD SCH MED,DEPT MED & CLIN SCI,SAKYO KU,KYOTO 606,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiotrophin-1 (CT-1) is a novel cytokine that was discovered from mouse embryoid bodies by means of expression cloning. It induces hypertrophy in cultured myocytes by activating a gp130 signaling pathway. To investigate the expression of the CT-1 gene in both normal adult and genetically hypertensive rats, we cloned rat CT-1 cDNA. The amino acid sequence is 94% identical to that of mouse CT-1. A significant amount of CT-1 mRNA was expressed in the ventricle of adult rats and also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Northern blot analysis revealed that the CT-1 mRNA level is significantly augmented in the ventricle of 12-week-old spontaneously hypertensive rats-stroke prone/Izm at a stage of established hypertension, suggesting a possible relevance of CT-1 to ventricular hypertrophy. (C) 1996 Academic Press, Inc.

引用

页码：377 / 381

页数：5

共 14 条

[1] AUGMENTED EXPRESSION OF ATRIAL NATRIURETIC POLYPEPTIDE GENE IN VENTRICLES OF SPONTANEOUSLY HYPERTENSIVE RATS (SHR) AND SHR-STROKE PRONE [J].

ARAI, H ;

NAKAO, K ;

SAITO, Y ;

MORII, N ;

SUGAWARA, A ;

YAMADA, T ;

ITOH, H ;

SHIONO, S ;

MUKOYAMA, M ;

OHKUBO, H ;

NAKANISHI, S ;

IMURA, H .

CIRCULATION RESEARCH, 1988, 62 (05) :926-930

[2] TRANSGENIC RATS CARRYING THE MOUSE RENIN GENE - MORPHOLOGICAL CHARACTERIZATION OF A LOW-RENIN HYPERTENSION MODEL [J].

BACHMANN, S ;

PETERS, J ;

ENGLER, E ;

GANTEN, D ;

MULLINS, J .

KIDNEY INTERNATIONAL, 1992, 41 (01) :24-36

[3] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[4] A SIMPLE AND VERY EFFICIENT METHOD FOR GENERATING CDNA LIBRARIES [J].

GUBLER, U ;

HOFFMAN, BJ .

GENE, 1983, 25 (2-3) :263-269

[5] CONTINUOUS ACTIVATION OF GP130, A SIGNAL-TRANSDUCING RECEPTOR COMPONENT FOR INTERLEUKIN 6-RELATED CYTOKINES, CAUSES MYOCARDIAL HYPERTROPHY IN MICE [J].

HIROTA, H ;

YOSHIDA, K ;

KISHIMOTO, T ;

TAGA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4862-4866

[6]

ITOH H, 1991, CIRC RES, V69, P209

[7] ALPHA-1-ADRENERGIC RECEPTOR STIMULATION OF SARCOMERIC ACTIN ISOGENE TRANSCRIPTION IN HYPERTROPHY OF CULTURED RAT-HEART MUSCLE-CELLS [J].

LONG, CS ;

ORDAHL, CP ;

SIMPSON, PC .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (03) :1078-1082

[8] NATRIURETIC PEPTIDES AS CARDIAC HORMONES IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS - THE VENTRICLE IS A MAJOR SITE OF SYNTHESIS AND SECRETION OF BRAIN NATRIURETIC PEPTIDE [J].

OGAWA, Y ;

NAKAO, K ;

MUKOYAMA, M ;

HOSODA, K ;

SHIRAKAMI, G ;

ARAI, H ;

SAITO, Y ;

SUGA, S ;

JOUGASAKI, M ;

IMURA, H .

CIRCULATION RESEARCH, 1991, 69 (02) :491-500

[9] CARDIOTROPHIN-1 - BIOLOGICAL-ACTIVITIES AND BINDING TO THE LEUKEMIA INHIBITORY FACTOR-RECEPTOR GP130 SIGNALING COMPLEX [J].

PENNICA, D ;

SHAW, KJ ;

SWANSON, TA ;

MOORE, MW ;

SHELTON, DL ;

ZIONCHECK, KA ;

ROSENTHAL, A ;

TAGA, T ;

PAONI, NF ;

WOOD, WI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (18) :10915-10922

[10] EXPRESSION CLONING OF CARDIOTROPHIN-1, A CYTOKINE THAT INDUCES CARDIAC MYOCYTE HYPERTROPHY [J].

PENNICA, D ;

KING, KL ;

SHAW, KJ ;

LUIS, E ;

RULLAMAS, J ;

LUOH, SM ;

DARBONNE, WC ;

KNUTZON, DS ;

YEN, R ;

CHIEN, KR ;

BAKER, JB ;

WOOD, WI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) :1142-1146

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