Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis

被引：183

作者：

Lindfors, N. C. ^{[1
]}

Hyvonen, P. ^{[2
]}

Nyyssonen, M. ^{[3
]}

Kirjavainen, M. ^{[1
]}

Kankare, J. ^{[1
]}

Gullichsen, E. ^{[4
]}

Salo, J. ^{[1
]}

机构：

[1] Univ Helsinki, Cent Hosp, Dept Orthopaed & Hand Surg, Helsinki, Finland

[2] Oulu Univ Hosp, Dept Orthopaed & Traumatol, Oulu, Finland

[3] N Karelia Cent Hosp, Dept Orthopaed & Traumatol, Joensuu, Finland

[4] Turku Univ Hosp, Dept Orthopaed & Traumatol, FIN-20520 Turku, Finland

来源：

BONE | 2010年 / 47卷 / 02期

关键词：

Bioactive glass; Bone substitute; Osteomyelitis; Antibacterial; Osteoconductive; CALCIUM-PHOSPHATE FORMATION; AUTOGENOUS BONE; IN-VITRO; ANGIOGENESIS; BACTERIA; SURFACE; GROWTH; CEMENT; TUMORS;

D O I：

10.1016/j.bone.2010.05.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：212 / 218

页数：7

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