Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency

被引：18

作者：

El-Khairi, Ranna ^{[1
]}

Parnaik, Rahul ^{[1
]}

Duncan, Andrew J. ^{[1
]}

Lin, Lin ^{[1
]}

Gerrelli, Dianne ^{[2
]}

Dattani, Mehul T. ^{[1
]}

Conway, Gerard S. ^{[3
]}

Achermann, John C. ^{[1
]}

机构：

[1] UCL, Dev Endocrinol Res Grp, Clin & Mol Genet Unit, Inst Child Hlth, London WC1N 1EH, England

[2] UCL, Neural Dev Unit, Inst Child Hlth, London WC1N 1EH, England

[3] Univ Coll London Hosp, Dept Endocrinol, London NW1 2PQ, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 351卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Lin28A; Lin28B; Primary ovarian insufficiency (POI); Premature ovarian failure (POF); Germ cell; GENOME-WIDE ASSOCIATION; GERM-CELLS; AGE; EXPRESSION; VARIANTS;

D O I：

10.1016/j.mce.2011.12.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lin28 proteins are emerging as important regulators of microRNAs in endocrine systems. Lin28a regulates primordial germ cell development and puberty timing in mice, whereas the related protein LIN28B is associated with age at menarche in genome-wide association studies in humans. Here, we studied expression of LIN28A and LIN28B in early human gonad development. LIN28A increased in the developing ovary between 6 and 9 weeks post conception, but not in the developing testis. Immunohistochemistry demonstrated LIN28A in peripheral germ cells. LIN28B was expressed at lower levels in both tissues and did not increase with time. As disruption of Lin28a affects germ cell development in mice. LIN28A was considered a candidate gene for primary ovarian insufficiency (POI) in humans. However, no significant changes were found in 50 women studied. These findings show LIN28A is strongly expressed in germ cells during early human ovary development, but disruption of LIN28A is not a common cause of POI. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：264 / 268

页数：5