Is Adjuvant Chemotherapy Efficient in Colon Cancer with High Microsatellite Instability? A Look Towards the Future

被引：5

作者：

Schiappacasse Cocio, Guido V. ^{[1
,2
,3
]}

Schiappacasse, Enrico D. ^{[4
]}

机构：

[1] Clin Hosp Vina del Mar, Dept Med Oncol, Vina Del Mar, Chile

[2] Bupa Renaca Clin, Dept Med Oncol, Vina Del Mar, Chile

[3] Ciudad Mar Clin, Dept Med Oncol, Vina Del Mar, Chile

[4] Tufts Univ, Grad Sch Arts & Sci, Medford, MA 02155 USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 03期

关键词：

STAGE-II; OXALIPLATIN; 5-FLUOROURACIL; FLUOROURACIL; LEUCOVORIN; SURVIVAL; MUTATION;

D O I：

10.1158/0008-5472.CAN-18-2991

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The high microsatellite instability (MSI-H) is frequently observed in localized colorectal adenocarcinoma. MSI-H is a good prognostic factor in nonmetastatic colon adenocarcinoma. However, MSI-H is not a predictive factor because it is not related with better survival in patients with colon cancer with adjuvant chemotherapy. MSI-H should be a predictive factor because it is associated with a higher expression of enzymes, which are inhibited by cytotoxic agents. Here, we analyze this controversy. We conclude MSI-H is not a predictive factor because the adjuvant therapy based on traditional cytotoxic agents does not act on either immune signaling pathways or BRAF mutation.

引用

页码：441 / 444

页数：4

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