The Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: on Subsets and Subsites

被引：66

作者：

Wondergem, Niels E. ^{[1
]}

Nauta, Irene H. ^{[1
]}

Muijlwijk, Tara ^{[1
]}

Leemans, C. Rene ^{[1
]}

van de Ven, Rieneke ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Otolaryngol Head & Neck Surg, Canc Ctr Amsterdam, Amsterdam UMC, De Boelelaan, NL-1117 Amsterdam, Netherlands

来源：

CURRENT ONCOLOGY REPORTS | 2020年 / 22卷 / 08期

关键词：

Head and neck squamous cell carcinoma; Tumor microenvironment; Innate and adaptive immune system; Tumor infiltrating lymphocytes; Prognosis; HNSCC subsites; TUMOR-INFILTRATING LYMPHOCYTES; CANCER-ASSOCIATED FIBROBLASTS; PLASMACYTOID DENDRITIC CELLS; HPV-ASSOCIATED HEAD; T-CELL; PROGNOSTIC-SIGNIFICANCE; ORAL-CAVITY; B-CELLS; LANGERHANS CELLS; CLINICOPATHOLOGICAL FEATURES;

D O I：

10.1007/s11912-020-00938-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PurposeTo understand why some patients respond to immunotherapy but many do not, a clear picture of the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) is key. Here we review the current understanding on the immune composition per HNSCC subsite, the importance of the tumor's etiology and the prognostic power of specific immune cells.Recent FindingsLarge cohort data are mostly based on deconvolution of transcriptional databases. Studies focusing on infiltrate localization often entail small cohorts, a mixture of HNSCC subsites, or focus on a single immune marker rather than the interaction between cells within the TME.SummaryConclusions on the prognostic impact of specific immune cells in HNSCC are hampered by the use of heterogeneous or small cohorts. To move forward, the field should focus on deciphering the immune composition per HNSCC subsite, in powered cohorts and considering the molecular diversity in this disease.

引用

页数：14

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