The putative gene for the first enzyme of glutathione biosynthesis in Plasmodium berghei and Plasmodium falciparum

被引：13

作者：

Birago, C ^{[1
]}

Pace, T ^{[1
]}

Picci, L ^{[1
]}

Pizzi, E ^{[1
]}

Scotti, R ^{[1
]}

Ponzi, M ^{[1
]}

机构：

[1] Ist Super Sanita, Lab Biol Cellulare, I-00161 Rome, Italy

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1999年 / 99卷 / 01期

关键词：

Plasmodium; gamma-glutamylcysteine synthetase; glutathione biosynthesis;

D O I：

10.1016/S0166-6851(98)00179-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The putative gene for gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis, has been characterized both in Plasmodium berghei and Plasmodium falciparum. Protein sequence comparison between these two species reveals large conserved regions sharing more than 80% similarity, separated by less conserved portions. When the comparison is extended to known gamma-glutamylcysteine synthetases from other eukaryotes, a number of high similarity blocks are observed which may help in identifying sequence essential for protein function. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：33 / 40

页数：8

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