Carbon-Sulfur Bond Formation of Challenging Substrates at Low Temperature by Using Pd-PEPPSI-IPent

被引：127

作者：

Sayah, Mahmoud ^{[1
]}

Organ, Michael G. ^{[1
]}

机构：

[1] York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 42期

关键词：

cross-coupling; palladium; PEPPSI; sulfination; ORTHO-SUBSTITUTED BIARYLS; PALLADIUM-CATALYZED SYNTHESIS; ARYL CHLORIDES; S-ARYLATION; EFFICIENT; THIOLS; THIOETHERS; SULFIDES; BROMIDES; IODIDES;

D O I：

10.1002/chem.201102158

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aryl thiols made cool and quick: The coupling of alkyl, aryl, and silyl thiols to hindered, deactivated aryl bromides and chlorides has been achieved under the most mild temperatures yet reported (i.e., room temperature to 40°C). The bulk afforded by the di-2,6-(3-propylphenyl)imidazolium-derived Pd-PEPPSI-IPent catalyst is believed to actively promote the critical reductive elimination step of the catalytic cycle, thereby eliminating the formation of poisonous off-cycle dimeric resting states that have plagued Pd-catalyzed sulfination reactions. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：11719 / 11722

页数：4

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