Is large birth weight associated with asthma risk in early childhood?

被引：10

作者：

To, Teresa ^{[1
,2
,3
,4
]}

Guan, Jun ^{[4
]}

Wang, Chengning ^{[1
]}

Radhakrishnan, Dhenuka ^{[1
]}

McLimont, Susan ^{[1
]}

Latycheva, Oxana ^{[5
]}

Gershon, Andrea S. ^{[1
,3
,4
,6
]}

机构：

[1] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[2] Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada

[4] Inst Clin Evaluat Sci, Toronto, ON, Canada

[5] Asthma Soc Canada, Toronto, ON, Canada

[6] Sunnybrook Hlth Sci Ctr, Dept Med, Toronto, ON M4N 3M5, Canada

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2012年 / 97卷 / 02期

基金：

加拿大健康研究院;

关键词：

COMPLEX CHRONIC CONDITIONS; POPULATION-BASED COHORT; FETAL-GROWTH; YOUNG-ADULTS; HAY-FEVER; ATOPY; CHILDREN; ONTARIO; MARKERS; SIZE;

D O I：

10.1136/adc.2010.187047

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To determine the association between large birth weight and the risk of developing asthma in early childhood. Methods All single live births (n = 687 194) born in Ontario between 1 April 1995 and 31 March 2001 were followed until their sixth birthday. Their birth weight was categorised as low (<2.5 kg), normal (2.5-4.5 kg), large (4.6-6.5 kg) or extremely large (>6.5 kg). Poisson regression analysis was used. Results Compared with normal-birth-weight infants, large-birth-weight infants (2.3% of total) had a slightly lower risk of developing asthma by age 6 after adjusting for confounders (adjusted RR 0.90, 95% CI 0.86 to 0.93). There was a trend towards increased risk of asthma among extremely large-birth-weight infants (RR 1.21, 95% CI 0.67 to 2.19). Conclusions Contrary to previous reports, large birth weight was associated with a lower risk for asthma. Instead, a trend towards increased risk of asthma was observed among extremely large-birth-weight infants and interventions to reduce the incidence of extreme large birth weight may help reduce the risk of asthma.

引用

页码：169 / 171

页数：3

共 28 条

[1] Is enhanced fetal growth a risk factor for the development of atopy or asthma?
Beasley, R
Leadbitter, P
Pearce, N
Crane, J
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1999, 118 (2-4) : 408 - 410
[2] The relation of markers of fetal growth with asthma, allergies and serum immunoglobulin E levels in children at age 5-7 years
Bolte, G
Schmidt, M
Maziak, W
Keil, U
Nasca, P
von Mutius, E
Weiland, SK
[J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2004, 34 (03) : 381 - 388
[3] Impact of low birth weight on early childhood asthma in the United States
Brooks, AM
Byrd, RS
Weitzman, M
Auinger, P
McBride, JT
[J]. ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 2001, 155 (03): : 401 - 406
[4] du Plessis., 2001, Rural and Small Town Canada Analysis Bulletin, V3, P1
[5] Size at birth, childhood growth and obesity in adult life
Eriksson, J
Forsén, T
Tuomilehto, J
Osmond, C
Barker, D
[J]. INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (05) : 735 - 740
[6] Feudtner C, 2000, PEDIATRICS, V106, P205
[7] Deaths attributed to pediatric complex chronic conditions: National trends and implications for supportive care services
Feudtner, C
Hays, RM
Haynes, G
Geyer, JR
Neff, JM
Koepsell, TD
[J]. PEDIATRICS, 2001, 107 (06) : E99
[8] A meta-analysis of the effect of high weight on asthma
Flaherman, V
Rutherford, GW
[J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2006, 91 (04) : 334 - 339
[9] Identifying patients with physician-diagnosed asthma in health administrative databases
Gershon, Andrea S.
Wang, Chengning
Guan, Jun
Vasilevska-Ristovska, Jovanka
Cicutto, Lisa
To, Teresa
[J]. CANADIAN RESPIRATORY JOURNAL, 2009, 16 (06) : 183 - 188
[10] Diabetes in Ontario - Determination of prevalence and incidence using a validated administrative data algorithm
Hux, JE
Flintoft, V
Ivis, F
Bica, A
[J]. DIABETES CARE, 2002, 25 (03) : 512 - 516

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