Spotlight Golden Anniversary of the Nicotinic Receptor

被引：6

作者：

Changeux, Jean-Pierre ^{[1
,2
]}

机构：

[1] Inst Pasteur, CNRS, UMR 3571, Dept Neurosci, F-75005 Paris, France

[2] Coll France, F-75005 Paris, France

来源：

NEURON | 2020年 / 107卷 / 01期

关键词：

ACETYLCHOLINE-RECEPTOR; TRANSITIONS;

D O I：

10.1016/j.neuron.2020.05.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The high-resolution structure of the nicotinic acetylcholine receptor from Torpedo electric tissue in association with the snake toxin alpha-bungarotoxin (Rahman et al., 2020) is presented 50 years after its identification as the first neurotransmitter receptor and ligand-gated ion channel.

引用

页码：14 / 16

页数：3

共 11 条

[1] PRESENCE OF A LATTICE STRUCTURE IN MEMBRANE FRAGMENTS RICH IN NICOTINIC RECEPTOR PROTEIN FROM ELECTRIC ORGAN OF TORPEDO-MARMORATA [J].

CARTAUD, J ;

BENEDETTI, EL .

FEBS LETTERS, 1973, 33 (01) :109-113

[2] The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation [J].

Cecchini, Marco ;

Changeux, Jean-Pierre .

NEUROPHARMACOLOGY, 2015, 96 :137-149

[3]

Changeux J.P., 2012, BRAIN CHEM MACHINE N

[4] USE OF A SNAKE VENON TOXIN TO CHARACTERIZE CHOLINERGIC RECEPTOR PROTEIN [J].

CHANGEUX, JP ;

KASAI, M ;

LEE, CY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 67 (03) :1241-+

[5]

KARLIN A, 1983, J BIOL CHEM, V258, P6678

[6] PHOTOAFFINITY-LABELING OF THE ACETYLCHOLINE BINDING-SITES ON THE NICOTINIC RECEPTOR BY AN ARYLDIAZONIUM DERIVATIVE [J].

LANGENBUCHCACHAT, J ;

BON, C ;

MULLE, C ;

GOELDNER, M ;

HIRTH, C ;

CHANGEUX, JP .

BIOCHEMISTRY, 1988, 27 (07) :2337-2345

[7] ON NATURE OF ALLOSTERIC TRANSITIONS - A PLAUSIBLE MODEL [J].

MONOD, J ;

WYMAN, J ;

CHANGEUX, JP .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 12 (01) :88-&

[8] CROSSLINKING OF ALPHA-BUNGAROTOXIN TO THE ACETYLCHOLINE-RECEPTOR FROM TORPEDO-MARMORATA BY ULTRAVIOLET-LIGHT IRRADIATION [J].

OSWALD, RE ;

CHANGEUX, JP .

FEBS LETTERS, 1982, 139 (02) :225-229

[9] ACETYLCHOLINE-RECEPTOR - COMPLEX OF HOMOLOGOUS SUBUNITS [J].

RAFTERY, MA ;

HUNKAPILLER, MW ;

STRADER, CD ;

HOOD, LE .

SCIENCE, 1980, 208 (4451) :1454-1457

[10] Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins [J].

Rahman, Md. Mahfuzur ;

Teng, Jinfeng ;

Worrell, Brady T. ;

Noviello, Colleen M. ;

Lee, Myeongseon ;

Karlin, Arthur ;

Stowell, Michael H. B. ;

Hibbs, Ryan E. .

NEURON, 2020, 106 (06) :952-+

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