Midterm follow-up of a randomized trial of open surgery versus laparoscopic surgery in elderly patients with colorectal cancer

被引：34

作者：

Ishibe, Atsushi ^{[1
]}

Ota, Mitsuyoshi ^{[2
]}

Fujii, Shoichi ^{[2
]}

Suwa, Yusuke ^{[1
,2
,3
]}

Suzuki, Shinsuke ^{[1
,2
,3
]}

Suwa, Hirokazu ^{[1
,2
,3
]}

Momiyama, Masashi ^{[1
]}

Watanabe, Jun ^{[1
]}

Watanabe, Kazuteru ^{[1
]}

Taguri, Masataka ^{[3
]}

Kunisaki, Chikara ^{[2
]}

Endo, Itaru ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Surg Gastroenterol, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Surg, Gastroenterol Ctr, Yokohama, Kanagawa, Japan

[3] Yokohama City Univ, Grad Sch Med, Dept Biostat, Yokohama, Kanagawa, Japan

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2017年 / 31卷 / 10期

关键词：

Laparoscopic surgery; Elderly patient; Colorectal cancer; Randomized study; LATERAL NODE DISSECTION; MRC CLASICC TRIAL; RECTAL-CANCER; ASSISTED RESECTION; CLINICAL-TRIAL; TERM OUTCOMES; COLON-CANCER; MULTICENTER; MORTALITY; MORBIDITY;

D O I：

10.1007/s00464-017-5418-z

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Laparoscopic surgery has been widely accepted for the treatment of colorectal cancer; however, long-term outcomes in elderly patients remain controversial. The midterm results of a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer are presented. This was a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer. The primary outcome was complication rate, and secondary outcomes included 3-year recurrence-free survival and overall survival. A total of 200 patients were randomly assigned to open surgery or laparoscopic surgery between 2008 and 2012. The main study objective was to compare the midterm outcomes of open surgery with those of laparoscopic surgery in elderly patients with colorectal cancer. This trial is registered with Clinical Trials.gov (NCT01862562). There were no differences between the laparoscopic surgery group and open surgery group in the 3-year overall survival rate (91.5% for laparoscopic surgery vs. 90.6% for open surgery, p = 0.638) or the 3-year recurrence-free survival rate (84.8% for laparoscopic surgery vs. 88.2% for open surgery, p = 0.324). The local recurrence rate was significantly higher in the laparoscopic surgery group than in the open surgery group in rectal cancer (13.8% for laparoscopic surgery vs. 0% for open surgery, p = 0.038). In subgroup analysis according to tumor location, there were no significant differences in the 3-year overall survival rate or 3-year recurrence-free survival rate between the two treatment groups. The midterm outcomes of laparoscopic surgery are similar to those of open surgery in elderly patients with colorectal cancer.

引用

页码：3890 / 3897

页数：8

共 23 条

[21] Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients [J].