Sexual differentiation: From genes to gender

被引：31
作者：
Migeon, CJ
Wisniewski, AB
机构：
[1] Johns Hopkins Univ, Sch Med, Johns Hopkins Med Inst, Dept Pediat,Div Pediat Endocrinol, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Dept Psychol, Behav Endocrinol Grp, Baltimore, MD 21218 USA
来源：
HORMONE RESEARCH | 1998年 / 50卷 / 05期
关键词：
gender; sex differentiation; genitalia; internal ducts; gonads;
D O I：
10.1159/000023285
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A person's sex can be considered across various levels. To illustrate, genes, hormones, and genitalia can all be considered physical markers of a person's sex. In addition to physical markers, behaviors such as gender role, gender identity and sexual orientation can be perceived as stereotypically male or female. The purpose of this review is to summarize current knowledge of sexual differentiation which emphasizes genetic and hormonal mechanisms that result in male and female development of gonads and genitalia. Finally, consideration is given to associations between genetic sex, gonadal sex, and hormonal sex with gender.
引用
收藏
页码：245 / 251
页数：7
相关论文
共 41 条
[1]  
[Anonymous], 1991, BIOGRAPHIES GENDER H
[2]   A DOSAGE SENSITIVE LOCUS AT CHROMOSOME XP21 IS INVOLVED IN MALE TO FEMALE SEX REVERSAL [J].
BARDONI, B ;
ZANARIA, E ;
GUIOLI, S ;
FLORIDIA, G ;
WORLEY, KC ;
TONINI, G ;
FERRANTE, E ;
CHIUMELLO, G ;
MCCABE, ERB ;
FRACCARO, M ;
ZUFFARDI, O ;
CAMERINO, G .
NATURE GENETICS, 1994, 7 (04) :497-501
[3]   THE ROLE OF THE SEX-DETERMINING REGION OF THE Y-CHROMOSOME (SRY) IN THE ETIOLOGY OF 46,XX TRUE HERMAPHRODITISM [J].
BERKOVITZ, GD ;
FECHNER, PY ;
MARCANTONIO, SM ;
BLAND, G ;
STETTEN, G ;
GOODFELLOW, PN ;
SMITH, KD ;
MIGEON, CJ .
HUMAN GENETICS, 1992, 88 (04) :411-416
[4]   Experiment of nurture: Ablatio penis at 2 months, sex reassignment at 7 months, and a psychosexual follow-up in young adulthood [J].
Bradley, SJ ;
Oliver, GD ;
Chernick, AB ;
Zucker, KJ .
PEDIATRICS, 1998, 102 (01)
[5]   CULTURED HUMAN-SKIN FIBROBLASTS - A MODEL FOR THE STUDY OF ANDROGEN ACTION [J].
BROWN, TR ;
MIGEON, CJ .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1981, 36 (01) :3-22
[6]   IDENTIFICATION OF A PUTATIVE STEROIDOGENIC FACTOR-I RESPONSE ELEMENT IN THE DAX-1 PROMOTER [J].
BURRIS, TP ;
GUO, WW ;
LE, T ;
MCCABE, ERB .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 214 (02) :576-581
[7]   DIFFERENTIATION OF MAMMALIAN EMBRYONIC GONAD [J].
BYSKOV, AG .
PHYSIOLOGICAL REVIEWS, 1986, 66 (01) :71-117
[8]   Sex reassignment at birth - Long-term review and clinical implications [J].
Diamond, M ;
Sigmundson, HK .
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 1997, 151 (03) :298-304
[9]   CONGENITAL ADRENAL-HYPERPLASIA .2. GENDER-RELATED BEHAVIOR AND ATTITUDES IN FEMALE SALT-WASTING AND SIMPLE-VIRILIZING PATIENTS [J].
DITTMANN, RW ;
KAPPES, MH ;
KAPPES, ME ;
BORGER, D ;
MEYERBAHLBURG, HFL ;
STEGNER, H ;
WILLIG, RH ;
WALLIS, H .
PSYCHONEUROENDOCRINOLOGY, 1990, 15 (5-6) :421-434
[10]  
Fechner PY, 1996, ACTA PAEDIATR JAPON, V38, P380
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