Mechanochemical Aliphatic Iodination (and Bromination) by Cascaded Cyclization

被引：7

作者：

Bal, Ankita ^{[1
]}

Dinda, Tarun Kumar ^{[1
]}

Mal, Prasenjit ^{[1
]}

机构：

[1] OCC Homi Bhabha Natl Inst, Natl Inst Sci Educ & Res NISER Bhubaneswar, Sch Chem Sci, PO Bhimpur Padanpur,Via Jatni, Bhubaneswar 752050, Odisha, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 03期

关键词：

Aliphatic iodination; Bifunctional reagents; Cascaded cyclization; Iodonium cation; Mechanochemistry; OXIDATIVE CYCLIZATION; EFFICIENT; SYSTEM; HETEROCYCLES; ROUTE; FORCE; TBHP;

D O I：

10.1002/ajoc.202200046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aliphatic iodination via mechanochemistry is a mammoth challenge due to the high polarizability and weak electrophilicity of iodonium cation (I+), and low bond dissociation energy of carbon iodine bond. Herein, the synthesis is demonstrated of oxazoline derivatives from N-allyl benzamides via mechanochemical cascaded cyclization and halogenation using N-iodo- and N-bromosuccinimides, respectively, as bifunctional reagents.

引用

页数：4

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