Successful and safe long-term treatment of cerebral aspergillosis with high-dose voriconazole guided by therapeutic drug monitoring

被引：8

作者：

Cojutti, Pier Giorgio ^{[1
,2
]}

Merelli, Maria ^{[3
]}

Allegri, Lorenzo ^{[1
,4
]}

Damante, Giuseppe ^{[1
,4
]}

Bassetti, Matteo ^{[1
,3
]}

Pea, Federico ^{[1
,2
]}

机构：

[1] Univ Udine, Dept Med, Udine, Italy

[2] Azienda Sanit Univ Integrata Udine, Santa Maria della Misericordia Univ Hosp, Inst Clin Pharmacol, Udine, Italy

[3] Azienda Sanit Univ Integrata Udine, Santa Maria della Misericordia Univ Hosp, Clin Infect Dis, Udine, Italy

[4] Azienda Sanit Univ Integrata Udine, Santa Maria della Misericordia Univ Hosp, Inst Med Genet, Udine, Italy

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2019年 / 85卷 / 01期

关键词：

clinical pharmacology; cytochrome P450; genetic polymorphism; infectious diseases; pharmacokinetics; therapeutic drug monitoring; CONCISE GUIDE; BRAIN-TISSUE; IMPLEMENTATION; MANAGEMENT; CYP2C19; SOCIETY;

D O I：

10.1111/bcp.13789

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We report the case of a patient who had cerebral aspergillosis after otorhinolaryngologic surgery and who was successfully and safely treated with high-dose voriconazole (200 mg q6h) for more than 1 year thanks to a TDM-guided approach coupled with pharmacological review and with genotyping of CYP2C19 polymorphisms. The findings support the idea that personalized medicine based on TDM coupled with the need of avoiding drug-drug interactions may be helpful for maximizing the net benefit (probability of efficacy vs. probability of adverse events) of voriconazole in the management of long-term treatment of cerebral aspergillosis.

引用

页码：266 / 269

页数：4

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