Hydroarylation of Alkynes Catalyzed by Nickel

被引：198

作者：

Nakao, Yoshiaki ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Kyoto 6158510, Japan

来源：

CHEMICAL RECORD | 2011年 / 11卷 / 05期

关键词：

alkynes; C-H functionalization; hydroarylation; Lewis acids; nickel; C-H BONDS; PYRIDINE-N-OXIDES; DIRECT ARYLATION; SELECTIVE ALKENYLATION; INTRAMOLECULAR ARYLCYANATION; CIS-ADDITION; ATOM ECONOMY; ACTIVATION; ARYL; CARBOCYANATION;

D O I：

10.1002/tcr.201100023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nickel catalysts derived from bis(1,5-cyclooctadiene) nickel [ Ni(cod)(2)] and trialkylphosphines effect hydroarylation of alkynes through functionalization of C-H bonds of arenes including benzo-fused five-membered heteroarenes, pyridine-N-oxides, pyridines, 2-pyridones, and perfluoroarenes. The reactions proceed with excellent stereo-and regioselectivity to give disubstituted arylethenes in good yields. Use of Lewis acid (LA) co-catalysts is crucial for success in reactions of imidazoles, pyridines, and 2-pyridones; it is possible that coordination of the LA to the nitrogen or oxygen functionalities of such substrates increases the reactivity of their C-H bonds towards nickel(0) species. DOI 10.1002/tcr.201100023

引用

页码：242 / 251

页数：10

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