The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

被引:230
作者
Park, Seong-Cheol [1 ]
Park, Yoonkyung [1 ,2 ]
Hahm, Kyung-Soo [1 ,3 ]
机构
[1] Chosun Univ, Res Ctr Proteineous Mat, Kwangju 501759, South Korea
[2] Chosun Univ, Dept Biotechnol, Kwangju 501759, South Korea
[3] Bioleaders Corp, Taejon 305500, South Korea
基金
新加坡国家研究基金会;
关键词
mode of action; lipopolysaccharide; quorum sensing; dental plaque; synergetic effect; HOST-DEFENSE PEPTIDES; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; ANTIBACTERIAL ACTIVITY; IN-VITRO; METHICILLIN RESISTANCE; HELICOBACTER-PYLORI; ESCHERICHIA-COLI; ACTION MECHANISM; IMMUNE-RESPONSE;
D O I
10.3390/ijms12095971
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms, which are microbial communities that cause serious chronic infections and dental plaque, form environments that enhance antimicrobial resistance. As a result, there is a continuous search to overcome or control such problems, which has resulted in antimicrobial peptides being considered as an alternative to conventional drugs. Antimicrobial peptides are ancient host defense effector molecules in living organisms. These peptides have been identified in diverse organisms and synthetically developed by using peptidomimic techniques. This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. In addition, combinations of antimicrobial peptides and conventional drugs were considered due to their synergetic effects and low cost for therapeutic treatment.
引用
收藏
页码:5971 / 5992
页数:22
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