An efficient one-pot synthesis of pyrimido[2,1-b][1,3]thiazine derivatives by reaction of activated acetylenes, thiouracils, and isocyanides

被引：26
|
作者：
Baharfar, Robabeh [1 ]
Baghbanian, Seyed Meysam [1 ]
Vahdat, Seyed Mohammad [2 ]
机构：
[1] Univ Mazandaran, Dept Chem, Babol Sar, Iran
[2] Islamic Azad Univ, Ayatollah Amoli Branch, Dept Chem, Amol, Iran
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 45期
关键词：
Pyrimido[2,1-b][1,3]thiazines; Isocyanides; Activated acetylenes; Multicomponent reaction; PYRIMIDINE; ACIDS;
D O I：
10.1016/j.tetlet.2011.09.008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedi-carboxylates, was trapped by thiouracils to yield a ketenimine intermediate, which cyclized and then rearranged to afford pyrimido[2,1-b][1,3]thiazines in good yields. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6018 / 6020
页数：3
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