An efficient one-pot synthesis of pyrimido[2,1-b][1,3]thiazine derivatives by reaction of activated acetylenes, thiouracils, and isocyanides

被引：26

作者：

Baharfar, Robabeh ^{[1
]}

Baghbanian, Seyed Meysam ^{[1
]}

Vahdat, Seyed Mohammad ^{[2
]}

机构：

[1] Univ Mazandaran, Dept Chem, Babol Sar, Iran

[2] Islamic Azad Univ, Ayatollah Amoli Branch, Dept Chem, Amol, Iran

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 45期

关键词：

Pyrimido[2,1-b][1,3]thiazines; Isocyanides; Activated acetylenes; Multicomponent reaction; PYRIMIDINE; ACIDS;

D O I：

10.1016/j.tetlet.2011.09.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedi-carboxylates, was trapped by thiouracils to yield a ketenimine intermediate, which cyclized and then rearranged to afford pyrimido[2,1-b][1,3]thiazines in good yields. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6018 / 6020

页数：3

共 31 条

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