The Neurobiology of Borderline Personality Disorder

被引：42

作者：

Perez-Rodriguez, Maria Mercedes ^{[1
]}

Bulbena-Cabre, Andrea ^{[1
,2
,3
]}

Nia, Anahita Bassir ^{[1
]}

Zipursky, Gillian ^{[1
]}

Goodman, Marianne ^{[1
,2
]}

New, Antonia S. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, One Gustave L Levy Pl, New York, NY 10029 USA

[2] VA Bronx Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Dept Psychiat, 130 W Kingsbridge Rd, Bronx, NY 10468 USA

[3] Autonomous Univ Barcelona UAB, Dept Psychiat & Forens Med, Campus UAB,Pl Civ, Barcelona 08193, Spain

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2018年 / 41卷 / 04期

关键词：

Borderline personality disorder; Alexithymia; Genetics; Emotion dysregulation; Impulsive aggression; Neuroimaging; Oxytocin; Opioids; WHITE-MATTER INTEGRITY; EMOTION REGULATION; AFFECTIVE INSTABILITY; ANTERIOR CINGULATE; OXYTOCIN RECEPTOR; STRUCTURAL CONNECTIVITY; CHILDHOOD MALTREATMENT; ATTACHMENT BEHAVIOR; SOCIAL EXCLUSION; FEMALE-PATIENTS;

D O I：

10.1016/j.psc.2018.07.012

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.

引用

页码：633 / +

页数：19

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