Prooxidant-antioxidant balance in the prostate and blood of rats with sulpyride-induced prostatic hyperplasia corrected with prostatilen

被引：1
|
作者：
Belostotskaya, LI [1 ]
Gomon, ON
Nikitchenko, YV
Chaika, LA
Bondar, VV
Dzyuba, VN
机构：
[1] VN Karazin Kharkov Natl Univ, Lab Gen Pharmacol, Drug Res Ctr, Kharkov, Ukraine
[2] VN Karazin Kharkov Natl Univ, Inst Biol, Dept Membrane Biophys, Kharkov, Ukraine
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 139卷 / 03期
关键词：
benign prostatic hyperplasia; lipid peroxidation; sulpyride; prostatilen;
D O I：
10.1007/s10517-005-0287-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of 30-day injections of sulpyride and treatment with Prostatilen on the development of prostatic hyperplasia and LPO in rats. Sulpyride induced proliferation of lateral lobes, increased the content of lipid hydroperoxides and glutathione peroxidase activity in the gland; in the blood this preparation increased lipid hydroperoxide concentration and decreased glutathione peroxidase and total antioxidant activity. Prostatilen prevented the development of hyperplasia and normalized the prooxidant-antioxidant balance in tissues, except total antioxidant activity of the blood.
引用
收藏
页码：334 / 336
页数：3
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