Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy

被引：13
|
作者：
Leon Rodriguez, Daniel A. [1 ]
David Carmona, F. [1 ]
Isabel Gonzalez, Clara [2 ]
Martin, Javier [1 ]
机构：
[1] CSIC, IPBLN, PTS, Granada, Spain
[2] Univ Ind Santander, Fac Salud, GIEM, Bucaramanga, Colombia
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
VITAMIN-D-RECEPTOR; DISEASE; SUSCEPTIBILITY; ASSOCIATION; SEVERITY; DENSITY; MALARIA; ALPHA; IL12B; MICE;
D O I：
10.1038/srep31263
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Vitamin D is an important modulator of the immune response. It acts over several immune cell types where the Vitamin D receptor (VDR) is expressed. Due to the high relevance of this signaling pathway, several studies have investigated the possible influence of genes involved in the metabolism of Vitamin D and its receptor in different human diseases. Here, we analyzed whether four single-nucleotide polymorphisms of the VDR gene (rs731236, rs7975232, rs1544410 and rs2228570) are involved in the susceptibility to infection by Trypanosoma cruzi and/or to chronic Chagas cardiomyopathy (CCC) in a Colombian endemic population for this parasite. Our results showed that the rs2228570*A allele is associated with CCC development (P = 4.46E-03, OR = 1.51). In summary, the data presented in this report suggest that variation within the VDR gene may affect the immune response against T. cruzi, increasing the probability of cardiac complications in infected individuals.
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页数：6
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