Emergence of NDM-1 Metallo-β-Lactamase in Pseudomonas aeruginosa Clinical Isolates from Serbia

被引：154

作者：

Jovcic, Branko ^{[1
]}

Lepsanovic, Zorica ^{[2
]}

Suljagic, Vesna ^{[2
]}

Rackov, Gorjana ^{[2
]}

Begovic, Jelena ^{[1
]}

Topisirovic, Ljubisa ^{[1
]}

Kojic, Milan ^{[1
]}

机构：

[1] Univ Belgrade, Inst Mol Genet & Genet Engn, Belgrade 11010, Serbia

[2] Mil Med Acad, Belgrade 11002, Serbia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 08期

关键词：

ESCHERICHIA-COLI; GENES;

D O I：

10.1128/AAC.00226-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This work reports, for the first time, the presence of New Delhi metallo-beta-lactamase 1 (NDM-1) in Pseudomonas aeruginosa. Moreover, this is the first report of the NDM-1 presence in the Balkan region. Cosmid gene libraries of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical isolates MMA83 and MMA533 were screened for the presence of metallo-beta-lactamases. Accordingly, both MMA83 and MMA533 carried the bla(NDM-1) gene. Pulsed-field gel electrophoresis (PFGE) analysis indicated that strains MMA83 and MMA533 belonged to different clonal groups. Five additional isolates from different patients clonally related to either MMA83 or MMA533 were found to be NDM-1 positive.

引用

页码：3929 / 3931

页数：3

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