Factor V Leiden and pulmonary embolism in a young woman taking an oral contraceptive

被引：6

作者：

DiSiena, MR ^{[1
]}

Intres, R ^{[1
]}

Carter, DJ ^{[1
]}

机构：

[1] Berkshire Med Ctr, Dept Pathol, Pittsfield, MA 01201 USA

来源：

AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY | 1998年 / 19卷 / 04期

关键词：

venous thromboembolus; pulmonary emboli; activated protein C; factor C Leiden; oral contraceptive;

D O I：

10.1097/00000433-199812000-00013

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A 34-year-old woman with a history of asthma and oral contraceptive use died suddenly. Autopsy examination showed chronic pulmonary emboli with an acute pulmonary saddle embolus. An underlying congenital thrombophilic disorder was considered. Molecular studies on DNA isolated from blood using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis revealed coagulation factor V Leiden mutation. The incidence of venous thromboembolism in patients with factor V Leiden mutation and associated activated protein C (APC) resistance is discussed.

引用

页码：362 / 367

页数：6

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