Glucose repression on RIM1, a gene encoding a mitochondrial single-stranded DNA-binding protein, in Saccharomyces cerevisiae:: a possible regulation at pre-mRNA splicing

被引：7
|
作者：
Li, ZJ
Ling, F
Shibata, T [1 ]
机构：
[1] Inst Phys & Chem Res, RIKEN, Cellular & Mol Biol Lab, Wako, Saitama 3510198, Japan
[2] Saitama Univ, Grad Sch Sci & Engn, Urawa, Saitama 3380825, Japan
来源：
CURRENT GENETICS | 1998年 / 34卷 / 05期
基金：
日本科学技术振兴机构;
关键词：
SSB-homolog; regulation; gene expression; budding yeast; glucose effect;
D O I：
10.1007/s002940050406
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The mitochondrial single-stranded DNA-binding protein (SSB) encoded by a nuclear gene, RIM1, is a homolog of Escherichia coli SSB. The addition of glucose decreased the amount of RIM1-mRNA in cells growing in a glycerol medium, but increased the amount of the immature RIM1-mRNA. The changes in the amounts of both mature and immature RIM1-mRNAs were dependent on SRN1/REG1/HEX2, a gene relating to pre-mRNA-splicing and glucose repression. These observations suggest that the expression of the mitochondrial SSB is regulated, at least in part, by pre-mRNA splicing under the control of glucose repression.
引用
收藏
页码：351 / 359
页数：9
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