Genome of the host-cell transforming parasite Theileria annulata compared with T-parva

被引：246
作者：
Pain, A
Renauld, H
Berriman, M
Murphy, L
Yeats, CA
Weir, W
Kerhornou, A
Aslett, M
Bishop, R
Bouchier, C
Cochet, M
Coulson, RMR
Cronin, A
de Villiers, EP
Fraser, A
Fosker, N
Gardner, M
Goble, A
Griffiths-Jones, S
Harris, DE
Katzer, F
Larke, N
Lord, A
Maser, P
McKellar, S
Mooney, P
Morton, F
Nene, V
O'Neil, S
Price, C
Quail, MA
Rabbinowitsch, E
Rawlings, ND
Rutter, S
Saunders, D
Seeger, K
Shah, T
Squares, R
Squares, S
Tivey, A
Walker, AR
Woodard, J
Dobbelaere, DAE
Langsley, G
Rajandream, MA
McKeever, D
Shiels, B
Tait, A
Barrell, B
Hall, N
机构：
[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[2] Moredun Res Inst, Penicuik EH26 0PZ, Midlothian, Scotland
[3] Univ Bern, Inst Anim Pathol, CH-3012 Bern, Switzerland
[4] Univ Bern, Inst Cell Biol, CH-3012 Bern, Switzerland
[5] Easter Bush Vet Ctr, Royal Sch Vet Studies, Div Vet Clin Studies, Roslin EH25 9RG, Midlothian, Scotland
[6] Inst Genom Res, TIGR, Rockville, MD 20850 USA
[7] European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, England
[8] Inst Pasteur, Dept Parasitol, CNRS, URA 2581, F-75724 Paris, France
[9] Inst Pasteur, Plate Forme Genom Pasteur Genopole Ile France, F-75724 Paris, France
[10] Int Livestock Res Inst, Nairobi, Kenya
[11] Fac Vet Med, Inst Comparat Med, Parasitol Grp, Div Vet Infect & Immun, Glasgow G61 1QH, Lanark, Scotland
来源：
SCIENCE | 2005年 / 309卷 / 5731期
关键词：
D O I：
10.1126/science.1110418
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
引用
收藏
页码：131 / 133
页数：3
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