Plasmonic engineering of singlet oxygen generation

被引：161

作者：

Zhang, Yongxia ^{[1
,2
]}

Aslan, Kadir ^{[1
,2
]}

Previte, Michael J. R. ^{[1
,2
]}

Geddes, Chris D. ^{[1
,2
]}

机构：

[1] Univ Maryland, Inst Biotechnol, Inst Fluorescence, Lab Adv Med Plasmon, Baltimore, MD 21201 USA

[2] Univ Maryland, Inst Biotechnol, Ctr Med Biotechnol, Lab Adv Fluorescence Spect, Baltimore, MD 21201 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 06期

关键词：

metal-enhanced fluorescence; metal-enhanced phosphorescence; photodynamic therapy; surface-enhanced fluorescence;

D O I：

10.1073/pnas.0709501105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this article, we report metal-enhanced singlet oxygen generation ((MEO2)-O-1). We demonstrate a direct relationship between the singlet oxygen yield of a common photosensitizer (Rose Bengal) and the theoretical electric field enhancement or enhanced absorption of the photosensitizer in proximity to metallic nanoparticles. Using a series of photosensitizers, sandwiched between silver island films (SiFs), we report that the extent of singlet oxygen enhancement is inversely proportional to the free space singlet oxygen quantum yield. By modifying plasmon coupling parameters, such as nanoparticle size and shape, fluorophore/particle distance, and the excitation wavelength of the coupling photosensitizer, we can readily tune singlet oxygen yields for applications in singlet oxygen-based clinical therapy.

引用

页码：1798 / 1802

页数：5

共 31 条

[1] Efficient modeling of infinite scatterers using a generalized total-field/scattered-field FDTD boundary partially embedded within PML [J].