Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer's disease: mechanism of neuron death

被引：68
作者：
Burke, WJ
Li, SW
Schmitt, CA
Xia, P
Chung, HD
Gillespie, KN
机构：
[1] St Louis Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] St Louis Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[3] St Louis Univ, Sch Med, Dept Anat, St Louis, MO 63110 USA
[4] St Louis Univ, Sch Med, Dept Chem, St Louis, MO 63110 USA
[5] St Louis Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
[6] Vet Affairs Med Ctr, Sch Publ Hlth, St Louis, MO USA
来源：
BRAIN RESEARCH | 1999年 / 816卷 / 02期
关键词：
3,4-dihydroxyphenylglycolaldehyde; neurotoxin; locus ceruleus; neuron death; Alzheimer's disease;
D O I：
10.1016/S0006-8993(98)01211-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). NE neurons in the locus ceruleus (LC) die in Alzheimer's disease (AD). To determine if DOPEGAL could contribute to NE neuron death in AD we measured levels of DOPEGAL, NE and their synthesizing enzymes in LC from AD and matched controls. We found 2.8-and 3.6-fold increases in DOPEGAL and MAO-A in AD LC neuronal cell bodies compared to controls. NE and dopamine beta-hydroxylase were increased by 3.8- and 10.7-fold, respectively. Implications for the mechanism of neuron death in AD are discussed. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：633 / 637
页数：5
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