Quality Co68Fe4.5Si15B12.5 amorphous wires are fabricated and their giant magneto impedance (GMI) effect are investigated at frequencies ranging from 0.1 to 20 MHz with or without tensile stress applied. Experimental results indicate that the GMI effect of these wires can be effectively improved by applying a small axial tensile stress. There is a pronounced increase from 1.3% to 47.3% in impedance ratio at 0.6 MHz when a stress of 103 MPa is applied. The GMI response is further increased to 261% by doing so at 15 MHz. The field sensitivity of these wires is optimized and it increases from 0.55 to 2.73%/(A/m) at 0.6 MHz and it is proved that the most sensitive field response is obtained by applying a tensile stress of 84.5 MPa below 1 MHz. With reference to the stress evolution of sensitivity at varying frequencies, the maximum field sensitivity shifts to a lower stress with increasing frequency. Quantitatively, a stress as small as 18.4 MPa is enough to yield a field sensitivity as high as 6.7%/(A/m) at 15 MHz. This demonstrates the possibility of achieving small stress (<100 MPa) induced large enhancement of GMI effect and field sensitivity at frequencies of several tens of MHz that are of much technical interest in sensor applications. (C) 2011 Elsevier B.V. All rights reserved.