Testicular germ cell tumours: predisposition genes and the male germ cell niche

被引：73

作者：

Gilbert, Duncan ^{[1
,2
]}

Rapley, Elizabeth ^{[1
]}

Shipley, Janet ^{[1
]}

机构：

[1] Inst Canc Res, Male Urol Canc Res Ctr, Sutton SM2 5NG, Surrey, England

[2] Royal Sussex Cty Hosp, Sussex Canc Ctr, Brighton BN2 5BE, E Sussex, England

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 04期

基金：

英国医学研究理事会;

关键词：

ANDROGEN RECEPTOR GENE; SPERMATOGONIAL STEM-CELLS; CARCINOMA-IN-SITU; GASTROINTESTINAL STROMAL TUMORS; RAS SIGNALING PATHWAYS; LONG-TERM SURVIVORS; LUNG-CANCER CELLS; OF-THE-LITERATURE; BREAST-CANCER; C-KIT;

D O I：

10.1038/nrc3021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Testicular germ cell tumours (TGCTs) of adults and adolescents are putatively derived from primordial germ cells or gonocytes. Recently reported genome-wide association studies implicate six gene loci that predispose to TGCT development. Remarkably, the functions of proteins encoded by genes within these regions bridge our understanding between the pathways involved in primordial germ cell physiology, male germ cell development and the molecular pathology of TGCTs. Furthermore, this improved understanding of the mechanisms underlying TGCT development and dissemination has clinical relevance for the management of patients with these tumours.

引用

页码：278 / 288

页数：11

共 199 条

[1] Does a testicular dysgenesis syndrome exist? [J].

Akre, Olof ;

Richiardi, Lorenzo .

HUMAN REPRODUCTION, 2009, 24 (09) :2053-2060

[2] Epigenetics and the germline [J].

Allegrucci, C ;

Thurston, A ;

Lucas, E ;

Young, L .

REPRODUCTION, 2005, 129 (02) :137-149

[3] Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours [J].

Almstrup, K ;

Hoei-Hansen, CE ;

Nielsen, JE ;

Wirkner, U ;

Ansorge, W ;

Skakkebæk, NE ;

Rajpert-De Meyts, E ;

Leffers, H .

BRITISH JOURNAL OF CANCER, 2005, 92 (10) :1934-1941

[4] Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1) [J].

Ara, T ;

Nakamura, Y ;

Egawa, T ;

Sugiyama, T ;

Abe, K ;

Kishimoto, T ;

Matsui, Y ;

Nagasawa, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5319-5323

[5] Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene [J].

Aschim, EL ;

Nordenskjöld, A ;

Giwercman, A ;

Lundin, KB ;

Ruhayel, Y ;

Haugen, TB ;

Grotmol, T ;

Giwercman, YL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) :5105-5109

[6]

ATKIN NB, 1982, LANCET, V2, P1349

[7] I(12P) - SPECIFIC CHROMOSOMAL MARKER IN SEMINOMA AND MALIGNANT TERATOMA OF THE TESTIS [J].

ATKIN, NB ;

BAKER, MC .

CANCER GENETICS AND CYTOGENETICS, 1983, 10 (02) :199-204

[8] Fertility patterns prior to testicular cancer diagnosis [J].

Baker, JA ;

Buck, GM ;

Vena, JE ;

Moysich, KB .

CANCER CAUSES & CONTROL, 2005, 16 (03) :295-299

[9] Characterization of deletions at 9p affecting the candidate regions for sex reversal and deletion 9p syndrome by MLPA [J].

Barbaro, Michela ;

Balsamo, Antonio ;

Anderlid, Britt Marie ;

Myhre, Anne Grethe ;

Gennari, Monia ;

Nicoletti, Annalisa ;

Pittalis, Maria Carla ;

Oscarson, Mikael ;

Wedell, Anna .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2009, 17 (11) :1439-1447

[10]

Barbero S, 2003, CANCER RES, V63, P1969

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